Results 51 to 60 of about 74,401 (248)

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Islamic Guidance and Counseling to Foster Gratitude in Boarding High School Students

Bulletin of Counseling and Psychotherapy
This study investigates the application of Islamic guidance and counseling to foster gratitude among students at Madrasah Aliyah (Islamic senior high school) Syekh Abdul Qodir Al-Jailani, Probolinggo.
Muhammad Ivan Dwi Saputra, Najlatun Naqiyah, Denok Setiawati, Bambang Dibyo Wiyono, Muhammad Farid Ilhamuddin, Bakhrudin All Habsy   +5 more
doaj   +1 more source

Gratitude in Organizations: A Contribution for Healthy Organizational Contexts

Frontiers in Psychology, 2017
This article reviews the construct of gratitude. Gratitude has been shown to be a fundamental resource for strengthening individual well-being. From a positive psychology perspective, gratitude is recognized as a promising opportunity for individuals ...
Annamaria Di Fabio, Letizia Palazzeschi, Ornella Bucci   +2 more
doaj   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

A Fentanyl‐Responsive Microneedle Patch for Harm Reduction

Advanced Science, EarlyView.
A fentanyl‐responsive microneedle patch is developed as a self‐regulating overdose intervention that releases naloxone upon detecting fentanyl. The system employs aptamer‐functionalized nanoparticles embedded in a swellable polymer matrix to enable rapid, on‐demand drug delivery through the skin.
Penghui Zhao, Zerui Zhou, Tyler Wolter, Huanqing Niu, Yuanzhi Bian, Chixia Tian, Chun Xu, Chenming Zhang, Juhong Chen, Matthew W. Buczynski, Wujin Sun   +10 more
wiley   +1 more source

Secular and Spiritual Gratitude: Impacts on Mood, Stress, Spirituality and Sense of Gratitude

Forum Pedagogiczne
This study examined the hypothesis that writing a secularly- or spiritually-oriented gratitude letter would show benefits for levels of gratitude, stress, mood, and spirituality.
Kendall Clausen, Jalen Denhartog, Tobias Snow, Loren Toussaint   +3 more
doaj   +1 more source

Efektifitas Pelatihan Kebersyukuran Untuk Meningkatkan Kualitas Hidup pada Pasien Hipertensi

JIP (Jurnal Intervensi Psikologi), 2020
Gratitude training is one of the Islamic intervention that is able to improve quality of life in hypertension patients. It applied quasy experimental design with pretest-posttest with control group design. Participants consist of 23 hypertension patients
Indahria Sulistyarini
doaj   +1 more source

Gratitude Unveiled: Investigating Key Influencers and Effective Interventions for Enhancing Gratitude

International Journal of Social Science Research and Review
This study explores the multifaceted factors influencing gratitude and investigates the effectiveness of gratitude interventions and mindfulness practices in enhancing gratitude levels. Based on existing research, personality traits (e.g., extraversion and empathy), social support, and cultural background are hypothesized to significantly impact the ...
openaire   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source