Results 81 to 90 of about 2,105,545 (239)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Leaving Past Adversities Behind: Gratitude Intervention Compensates for the Undesirable Effects of Past Time Perspectives on Negative Affect. [PDF]

Int J Environ Res Public Health, 2022
Burzynska-Tatjewska B, Stolarski M.
europepmc   +1 more source

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Strengthening the Subjective Well-being of People Living with HIV Through Gratitude Intervention in the Mahakam Plus Peer Support Group in Samarinda City

Warta LPM
People Living with HIV (PLHIV) often find themselves trapped in negative emotional states, such as feelings of distress and loss of life purpose. They frequently experience shame, marginalization, and a lack of motivation due to the stigma attached to ...
Diajeng Laily Hidayati, Lharasati Dewi, Dewi Indriani, Andi Muhammad Abdi   +3 more
doaj   +1 more source

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Being Thankful for What You Have: A Systematic Review of Evidence for the Effect of Gratitude on Life Satisfaction

Psychology Research and Behavior Management, 2023
Nicholas Kerry, Ria Chhabra, Jeremy DW Clifton Positive Psychology Center, University of Pennsylvania, Philadelphia, PA, USACorrespondence: Nicholas Kerry, Positive Psychology Center, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA, USA,
Kerry N, Chhabra R, Clifton JDW
doaj  

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Enhancing Meaning in Life and Psychological Well-Being Among a European Cohort of Young Adults via a Gratitude Intervention. [PDF]

Front Psychol, 2021
Czyżowska N, Gurba E.
europepmc   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Enhanced work engagement in Japanese employees following a 12-day online gratitude journal intervention

BMC Psychology
Background Gratitude interventions have shown various psychological benefits, including enhanced motivation in academic settings. However, their impact on work engagement - a key factor in employee well-being and organizational performance - remains ...
Noriko Yamagishi, Norberto Eiji Nawa, Shota Isomura   +2 more
doaj   +1 more source