Results 111 to 120 of about 18,970 (290)

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo   +7 more
wiley   +1 more source

Laser‐Based Sculpturing of Embedded Ultrathin Metal‐Oxide Nanopores for Enhanced Biomolecular Sensing

open access: yesAdvanced Functional Materials, EarlyView.
Controlled laser‐drilling of embedded HfO2 membranes creates three layer nanopores with Gaussian‐shaped cavities sculptured in the supporting layers. These embedded solid‐state nanopores slow DNA translocation by 12‐fold compared to SiNx pores, enabling high‐resolution, label‐free detection of short DNAs, RNAs, and proteins.
Jostine Joby   +4 more
wiley   +1 more source

ASPECTS OF THE FUNERARY RITE AND RITUAL IN THE SARMATIAN CEMETERY OF TIMIȘOARA-HLADIK 1 (TIMIȘ COUNTY). PRELIMINARY OBSERVATIONS

open access: yesJournal of Ancient History and Archaeology
This study, without aiming for comprehensiveness, attempts to present certain aspects of the funerary rite and ritual in the Sarmatae cemetery of Timișoara-Hladik 1 (Timiș county), wherea number of 139 inhumations and 16 ditched flat circular funerary ...
Vitalie BÂRCĂ   +3 more
doaj   +1 more source

Burying power: New insights into incipient leadership in the Late Pre-Pottery Neolithic from an outstanding burial at Ba'ja, southern Jordan.

open access: yesPLoS ONE, 2019
In 2016, an extraordinary burial of a young adult individual was discovered at the Late Pre-Pottery Neolithic B (LPPNB, 7,500-6,900 BCE) settlement of Ba'ja in southern Jordan.
Marion Benz   +7 more
doaj   +1 more source

Spirituality as a Process within the School Curriculum. [PDF]

open access: yes, 2003
Spiritual education concerns the quality of our thinking about ourselves, our relationships, our sense of worth and identity, and our sense of well-being. All curriculum subjects can contribute to this search for meaning. Religious education and the act
Bigger, Stephen
core   +1 more source

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

open access: yesAdvanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee   +4 more
wiley   +1 more source

Laser‐Induced Microfabrication of Carbon Nanostructure: Processing Mechanism and Application for Next‐Generation Battery Technology

open access: yesAdvanced Functional Materials, EarlyView.
The article reviews laser‐processed carbons from various precursors, processing mechanism and their application in advanced batteries. The laser process is chemical free, fast, and scalable, enabling improved battery performance and stability for Li, Na, and Zn battery technologies.
Sujit Deshmukh   +2 more
wiley   +1 more source

SERF Archive Report: Forteviot cist: strike-a-light [PDF]

open access: yes, 2018
The strike-a-light is part of the fire making kit recovered from the Forteviot cist during excavations undertaken by the SERF Project in ...
Wright, Dene
core  

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

open access: yesAdvanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang   +13 more
wiley   +1 more source

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