Results 221 to 230 of about 364,671 (298)

Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early‐Onset Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
This study identifies a unique physical signature of colorectal cancer in younger adults: their tissues are mechanically stiffer than those in older patients with the same cancer. Furthermore, stromal remodeling in early‐onset colorectal cancer promotes epithelial mechanotransduction and proliferation, showing how mechanical alterations in the tissue ...
Nicole C. Huning   +18 more
wiley   +1 more source

Th17-associated cytokine gene hypomethylation reflects epigenetic dysregulation in graves' disease. [PDF]

open access: yesFront Immunol
Jiang Y   +7 more
europepmc   +1 more source

Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges

open access: yesAdvanced Science, EarlyView.
This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li   +7 more
wiley   +1 more source

Thyrotropin and growth promoting immunoglobulin (TGI) of FRTL-5 cells have no growth stimulating activity on human thyroid epithelial cell cultures [PDF]

open access: yes, 1987
Bay, V.   +9 more
core  

Differentiated T Lymphocytes and Cancer Cell Mitochondrial Metabolism to Enhance Radioimmunotherapy by a Biomimetic Nanozyme System

open access: yesAdvanced Science, EarlyView.
T cell membrane‐coated MgCO3/Fe‐CD nanozyme loaded with TEPP‐46 (TFMP) enhances breast cancer radioimmunotherapy by reprogramming mitochondrial metabolism in T cells and tumors. It targets PD‐L1, converts H2O2 into ROS, neutralizes acidity, and releases Mg2⁺/TEPP‐46 to boost T cell activation.
Hanyu Zhang   +7 more
wiley   +1 more source

An in vitro model for thyroid autoimmunity [PDF]

open access: yes, 1987
AM McGregor   +12 more
core   +1 more source

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