Results 111 to 120 of about 8,829 (262)

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

Chemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup, Peter Reinholdt, Kasper Munch Beck, Michael Petersen, Jean‐Louis Mergny, Poul Nielsen   +5 more
wiley   +1 more source

Fibrilpaint: A Class of Amyloid‐Targeting Peptides

Chemistry – A European Journal, EarlyView.
FibrilPaints are modular peptides engineered to recognize amyloid fibrils. By systematically varying charge, sequence, and termini, their binding behavior can be tuned while retaining recognition. Successful binding ″paints″ fibrils for visualization and opens routes toward targeted degradation and diagnostic applications.
Júlia Aragonès Pedrola, Françoise A. Dekker, Katrin Guttmann, Litske M. van Leeuwen, Shalini Singh, Guy Mayer, Tommaso Garfagnini, Assaf Friedler, Stefan G. D. Rüdiger   +8 more
wiley   +1 more source

Review of CFD modelling techniques for single‐phase and multiphase flow in static mixers

The Canadian Journal of Chemical Engineering, EarlyView.
This review synthesizes computational fluid dynamics (CFD) approaches for static mixers, linking hydrodynamics to pressure drop, particle/droplet distributions, mixing metrics, and heat‐transfer performance to guide modelling choices and design decisions. Abstract Static mixers enable compact and low‐energy intensification.
Jussan Jaeger, Sálvio Lima de Carvalho Neto, Silvio Edegar Weschenfelder, Glaucia Rodrigues Vieira de Almeida da Fonseca, Maria de Fátima Rodrigues da Cunha, Selene Maria Arruda Guelli Ulson de Souza, Evandro Balestrin, Adriano da Silva   +7 more
wiley   +1 more source

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

Cytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Photothermal bubble: Dynamics, manipulation, and applications

Droplet, EarlyView.
As a versatile platform for bubble manipulation, photothermal techniques empower diverse operations: planar translation by scanning the laser spot, sustained periodic bouncing from competing thermal and hydrodynamic flows, and even guided 3D trajectories achieved by tailoring the heating configuration.
Man Hu, Feng Wang, Daosheng Deng
wiley   +1 more source

Global marine gravity field models at 1-arcminute resolution derived from optimized fusion of ICESat-2 along-track and cross-track measurements. [PDF]

Sci Data
Liu X, Xu Y, Peng H, Li Z, Bian S.
europepmc   +1 more source

Failure characteristics analysis of the inclined interlayer during water‐soluble cavity construction of underground salt caverns for large‐scale energy storage

Deep Underground Science and Engineering, EarlyView.
In the process of water‐soluble cavern construction of salt cavern energy storage, since the interlayer does not dissolve in water easily, sudden collapse will cause engineering accidents such as bending and damage of the inner tube of the cavern.
Zenghui Zhao, Tianyu Li, Qing Ma, Junlong Shang, Jiaze Du, Ruizhe He   +5 more
wiley   +1 more source

Deciphering the Protein Phosphorylation Dynamics Triggered by Seconds of Force Stimulation. [PDF]

Mol Cell Proteomics
Yang N, Sing Pun S, Wong EOY, Dai S, Li X, Leung M, Burlingame A, Wang ZY, Yang M, Lu Y, An Y, Zhang Y, Yang Z, Yu W, Li N.   +14 more
europepmc   +1 more source

The damage and failure mechanism of prestatically loaded rock during medium‐strain rate cyclic impact loading

Deep Underground Science and Engineering, EarlyView.
Based on experimental results and theoretical analysis, an established rock damage accumulation model that comprehensively considers the preapplied static load, impact peak value, impact frequency, and impact times. Abstract To study the rock damage mechanism under high static loading and superimposed medium strain rate cyclic impact loading, a series ...
Wei Wang, Hanpeng Wang, Zicheng Wang, Xinyuan Xie, Yunhao Wu, Jinhou Zhang, Dekang Sun   +6 more
wiley   +1 more source