Results 141 to 150 of about 16,583,366 (283)

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia

open access: yesAdvanced Science, EarlyView.
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Kai Song   +13 more
wiley   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong   +13 more
wiley   +1 more source

A New Feature Set for Texture-Based Classification of Remotely Sensed Images in a Quantum Framework

open access: yesJournal of Imaging
Texture feature extraction plays a crucial role in land-use and land-cover (LULC) classification for the remotely sensed images. However, when these images are quantized to a limited number of gray levels to reduce data volume or noise, conventional ...
Archana G. Pai   +3 more
doaj   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

open access: yesAdvanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu   +13 more
wiley   +1 more source

Fingerprint recognition system based on gray level co-occurrence matrix

open access: yes, 2017
The biometric system provides an automatic identification of any person, depending on characteristic and feature/attribution of person. Fingerprint is, today, one of the biometric systems that have a wide range of use in many investigation areas. Fingerprint, especially used for authentication, is more reliable comparing to the other traditional ...
openaire   +1 more source

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

open access: yesAdvanced Science, EarlyView.
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang   +9 more
wiley   +1 more source

Temporally Correlated Stochastic Spiking Neural Networks Enabled by 2D Ferroelectric Synapse‐Neuron Integration

open access: yesAdvanced Science, EarlyView.
We demonstrate a stochastic spiking neural network by integrating an α‐ln2Se3/h‐BN/CIPS FeFET synapse with an Au/CIPS/Au neuron. Unlike conventional memoryless stochastic neurons, the proposed neuron generates stochastic spikes through the evolution of internal ferroelectric polarization states, giving rise to intrinsic temporal correlations and ...
Hanseo Jeon   +7 more
wiley   +1 more source

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