Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan +10 more
wiley +1 more source
Topology‐Dependent Coke Formation in the Catalytic Pyrolysis of Phenol Over HFAU and HZSM‐5 Zeolites
The coke formation and speciation during the catalytic pyrolysis of lignin over different zeolite topologies were studied with a combination of operando EPR spectroscopy and ex situ pulsed techniques aided with DFT calculations. Operando EPR data showed that the coke formation in HFAU is fast compared to HZSM‐5.
Jörg W. A. Fischer +6 more
wiley +2 more sources
Research progress on biomarkers of traumatic brain injury
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen +8 more
wiley +1 more source
Reconfiguration of Multiphase Coacervate Droplets Into Self‐Regulated Nested Artificial Cells
Living cells advance functionality through spatiotemporal sub‐compartmentalization and internal organization. Herein, we develop a self‐regulated artificial cell by transforming a membrane‐less multiphase coacervate droplet (MCD) into a membranized, structurally reinforced nested coacervate vesicle (NCV).
Zhuping Yin +4 more
wiley +2 more sources
Estimation of Articular Cartilage Surface Roughness Using Gray-Level Co-Occurrence Matrix of Laser Speckle Image. [PDF]
Youssef D +4 more
europepmc +1 more source
Implementasi Gray Level Co-Occurrence Matrix (GLCM) Untuk Klasifikasi Penyakit Daun Padi
Bayu Setiaji, Arif Akbarul Huda
openaire +1 more source
Functional Segregation of Epileptogenicity within the Human Amygdala
Objective In temporal lobe epilepsy (TLE), the amygdala in the epileptogenic network is underestimated compared to other regions such as the hippocampus. Recent advances in anatomical neuroimaging and stereoelectroencephalography (SEEG) signal analyses could help better understand the involvement of the different amygdala nuclei in the genesis of ...
Odile Feys +14 more
wiley +1 more source
Quantitative distinction of the morphological characteristic of erythrocyte precursor cells with texture analysis using gray level co-occurrence matrix. [PDF]
Kono K +12 more
europepmc +1 more source
AI‐Driven Mapping of Seizure Spread Patterns
Objective The focus of epilepsy research has largely been on seizure onset; however, physicians typically examine the patterns of seizure spread past seizure onset as well. This study aims to align automated seizure analysis with clinical practice, leverage deep learning to standardize seizure annotations that varies among physicians, and understand ...
Andrew Y. Revell +13 more
wiley +1 more source
[Grading method of inhomogeneity of contrast-enhanced ultrasound for rectal tumors based on gray level co-occurrence matrix]. [PDF]
Luo Y +8 more
europepmc +1 more source

