Results 21 to 30 of about 1,223,099 (297)
BMC Medical Research Methodology, 2020 Background Awareness of model-based designs for dose-finding studies such as the Continual Reassessment Method (CRM) is now becoming more commonplace amongst clinicians, statisticians and trial management staff.
Erik van Werkhoven +7 more
doaj +1 more source
The oxic degradation of sedimentary organic matter 1400 Ma constrains atmospheric oxygen levels [PDF]
Biogeosciences, 2017 We studied sediments from the ca. 1400 million-year-old Xiamaling Formation from the North China block. The upper unit of this formation (unit 1) deposited mostly below storm wave base and contains alternating black and green-gray shales with very ...
S. Zhang +6 more
doaj +1 more source
Predictive Model for Opioid Use Disorder in Chronic Pain: A Development and Validation Study
BiomedicinesBackground/Objective: There are several questionnaires for the challenge of anticipating opioid use disorder (OUD). However, many are not specific for chronic non-cancer pain (CNCP) or have been developed in the American population, whose ...
Mónica Escorial +7 more
doaj +1 more source
Dynamical system analysis of ignition phenomena using the tangential stretching rate concept [PDF]
, 2015 We analyze ignition phenomena by resorting to the stretching rate concept formerly introduced in the study of dynamical systems. We construct a Tangential Stretching Rate (TSR) parameter by combining the concepts of stretching rate with the decomposition
Ciottoli, Pietro Paolo +4 more
core +1 more source
Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano +7 more
wiley +1 more source
BMC Ophthalmology, 2023 Purpose To evaluate the application of swept-source optical coherence tomography (SS-OCT) and pentacam scheimpflug tomography in posterior capsule opacification (PCO) severity assessment.
Yu Zhou +4 more
doaj +1 more source
Tropical and Subtropical Agroecosystems, 2022 Background. Gray fox, Urocyon cinereoargenteus is tolerant to habitat disturbance, but the biotic and abiotic factors that determine the selection of space in the subperennial medium forest (SMF) with different degrees of anthropization are not known ...
Ricardo Serna-Lagunes +7 more
doaj +1 more source
Homomorphisms of Gray-categories as pseudo algebras [PDF]
, 2014 Given Gray-categories $P$ and $L$, there is a Gray-category $\mathrm{Tricat}_{\mathrm{ls}}(P,L)$ of locally strict trihomomorphisms with domain $P$ and codomain $L$, tritransformations, trimodifications, and perturbations.
Buhné, Lukas
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
wiley +1 more source
Axonal transport impairment as an upstream mechanism in amyotrophic lateral sclerosis pathogenesis
Frontiers in NeuroscienceAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of upper and lower motor neurons. Despite marked genetic and pathological heterogeneity, a unifying pathogenic framework remains lacking.
Uri Gabbay, Uri Gabbay
doaj +1 more source