Results 61 to 70 of about 287,788 (298)

Managing healthcare for female BRCA carriers in the population screening era: developing a harmonized national policy for surveillance and risk-reduction

Israel Journal of Health Policy Research
Background The implementation of Israeli National screening for BRCA1/BRCA2 pathogenic variants (PVs) in 2020 has led to a significant increase in the number of unaffected female carriers who are referred to high-risk surveillance clinics (HRSCs).
Rachel Michaelson-Cohen, Shunit Armon, Naama Srebnik, Einat Koller Volkow, Pnina Mor, David Gekhtman, Ora Rosengarten, Adi Maisel Lotan, Hadar Goldvaser, Yahelli Miller, Dana Madorsky Feldman, Rinat Bernstein Molho, Miri Sklair Levy, Inbal Kedar, Yael Goldberg, Yael Raz, Sharon Simchoni, Aviad Hoffman, Miora Linial, Einat Carmon, Inbar Gatot, Michal Braha, Rakefet Chen Shtoyerman, Shikma Mordechai, Elizabeth E. Half, Lior Katz, Zohar Levi, Sharon Bratman Morag, Tanir M. Allweis, Eitan Friedman, Ephrat Levy-Lahad, Sari Lieberman   +31 more
doaj   +1 more source

Family matters: influenza vaccination uptake and associated factors in children aged 6 months–6 years

Frontiers in Public Health
BackgroundInfluenza poses significant health risks to young children, who are more vulnerable to severe complications. Despite effective vaccines, influenza vaccination rates among children are suboptimal.
Shirley Shapiro Ben David, Shirley Shapiro Ben David, Shiraz Vered, Limor Adler, Limor Adler, Daniella Rahamim Cohen, Afif Nakhleh, Afif Nakhleh, Afif Nakhleh, Yulia Binyaminov, Michal Stein, Michal Stein, Joseph Azuri, Joseph Azuri   +13 more
doaj   +1 more source

The Effect of Head Model Simplification on Beamformer Source Localization

Frontiers in Neuroscience, 2017
Beamformers are a widely-used tool in brain analysis with magnetoencephalography (MEG) and electroencephalography (EEG). For the construction of the beamformer filters realistic head volume conductor modeling is necessary for accurately computing the EEG
Frank Neugebauer, Gabriel Möddel, Stefan Rampp, Martin Burger, Carsten H. Wolters   +4 more
doaj   +1 more source

Assessment of CBCT gray value in different regions-of-interest and fields-of-view compared to Hounsfield unit [PDF]

, 2023
Atiye Yadegari, Yaser Safi, Soheil Shahbazi, Sahar Yaghoutiazar, Mitra Ghazizadeh Ahsaie   +4 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Empiric treatment and probability estimates before and after a decision support system intervention in a sore throat setting: a scenario-based survey study

BMC Infectious Diseases
Background Antimicrobial resistance poses challenges for physicians, who must balance individual patient care and public health when prescribing antibiotics. Machine learning-based computerized decision support systems (ML-CDSS) are increasingly proposed
Shoham Baruch, Maya Diamant, Yoav Ganzach, Zachi Grossman, Michal Stein, Uri Obolski   +5 more
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Intraepidermal Nerve Fiber Quantification of the Mouse Hind Paw Footpads: A Detailed and Simplified Protocol

Bio-Protocol
Small fiber neuropathy (SFN) is an underdiagnosed condition characterized by sensory and autonomic dysfunction due to impairment of small nerve fibers in skin, blood vessels, and internal organs.
Anastasia Yerushkin, Shani Berkowitz, Valery Golderman, Zehavit Goldberg, Yael Eshed-Eisenbach, Efrat Shavit-Stein, Amir Dori   +6 more
doaj   +1 more source

Adaptive Image Contrast Enhancement by Computing Distances into a 4-Dimensional Fuzzy Unit Hypercube

IEEE Access, 2017
A new fuzzy procedure for adaptive gray-level image contrast enhancement (CE) is presented in this paper. Starting from the pixels belonging to a normalized gray-level image, an appropriate smooth S-shaped fuzzy membership function (MF) is considered for
Mario Versaci, Francesco Carlo Morabito, Giovanni Angiulli   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source