Results 71 to 80 of about 1,223,099 (297)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The impact of shortening shifts of physicians during their residency on patients and physicians

Israel Journal of Health Policy Research
Background Prolonged shifts in residency contribute to physician fatigue, cognitive decline, and increased medical errors. This systematic review and meta-analysis evaluate how reducing shift length affects patient-physician safety, physician well-being,
Vered Daitch, Itamar Poran, Leonard Leibovici   +2 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Shocked zircons in the Onaping Formation: Further proof of impact origin [PDF]

The Onaping Formation fills the structural basin at Sudbury, Ontario, Canada. This formation is composed of three members: a basal, coarse, mainly quartzitic breccia (Basal Member); a light-colored, heavily included, polymict middle unit (Gray Member ...
Betterton, W. J., Bohor, B. F.
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Impact of sarcopenia and multifidus atrophy on outcomes from minimally invasive decompression surgery for lumbar spinal stenosis

North American Spine Society Journal
Background: In order to improve outcomes for patients with lumbar spinal stenosis, identification of better prognostic factors is necessary to guide patient selection for surgery.
Gilad J. Regev, MD, Uri Hochberg, MD, Dror Ofir, MD, Khalil Salame, MD, Zvi Lidar, MD, Morsi Khashan, MD   +5 more
doaj   +1 more source

Observations of Mare Serenitatis from lunar orbit and their interpretation [PDF]

Visual observations are investigated of color differences of Serenitatis mare materials from orbit complement photography and other remotely sensed data.
El-Baz, F., Evans, R. E.
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Sudbury project (University of Muenster-Ontario Geological Survey): Origin of the polymict, allochthonous breccias of the Onaping Formation [PDF]

The Sudbury structure has been interpreted as a deeply eroded remnant of a peak-ring basin. The polymict, allochthonous breccias of the Onaping Formation (OF) occur in the central part of the Sudbury structure, which is surrounded by the 1.85-Ga-old ...
Avermann, M. E.
core   +1 more source

Archeological Investigations on the Weyerhaeuser Land Exchange Sites, McCurtain County, Oklahoma: An Update [PDF]

, 2001
This paper provides a brief overview of the testing work completed to date on sites within the Tiak Ranger District. Ouachita National Forest. McCurtain County, Oklahoma.
Etchieson, Meeks
core   +1 more source