Results 281 to 290 of about 1,175,267 (351)

Total cost of ownership of heat pumps and policy choice: The case of Great Britain. [PDF]

iScience
Rosenow J, Barnes J, Galvin R, O'Mara S, Lowes R.   +4 more
europepmc   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Mapping the option space for carbon sequestration, food and biodiversity in Great Britain

Gall S, Harwood T, Obersteiner M, Hall J.   +3 more
europepmc   +1 more source

Impacts of agriculture and snow dynamics on catchment water balance in the U.S. and Great Britain. [PDF]

Commun Earth Environ
Zaerpour M, Hatami S, Ballarin AS, Knoben WJM, Papalexiou SM, Pietroniro A, Clark MP.   +6 more
europepmc   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

The Efficacy of Inoculated Small Pox in Promoting the Population of Great Britain.

R F Gillum
openalex   +1 more source

The effect of standardised packaging and limited flavour descriptors of vape pods among adults and youth in Great Britain: a cross-sectional between-subjects experimental study. [PDF]

Lancet Reg Health Eur
Taylor E, Ebdon M, Nottage M, Simonavicius E, Brose L, McNeill A, Arnott D, Cheeseman H, Bunce L, East K.   +9 more
europepmc   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

The closing longevity gap between battery electric vehicles and internal combustion vehicles in Great Britain. [PDF]

Nat Energy
Nguyen-Tien V, Zhang C, Strobl E, Elliott RJR.   +3 more
europepmc   +1 more source

The application of EPSiT in pilonidal sinus disease: an international Delphi consensus study endorsed by the Association of Laparoscopic Surgeons of Great Britain and Ireland (ALSGBI). [PDF]

Tech Coloproctol
Sekhon Inderjit Singh HK, Meinero P, Campanile FC, Quddus A, Rajaganeshan R, Warusavitarne J, Dotlacil V, Bhargava A, Giordano P, Pini Prato A, Shatkar V, Jalali P, Halahakoon VC, Gallo G, Milone M, Mantoo S, Leo CA, Esposito C, Farghaly M, Arulampalam T, Pawa N.   +20 more
europepmc   +1 more source