Results 61 to 70 of about 1,764,326 (320)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The Implementation of Hybrid Education at Sunergeo Theological Seminary Banten as a response to the Great Commission [PDF]

Pharos Journal of Theology
The research aimed to evaluate the level of preparedness and adaptability of Sunergeo Theological Seminary in using a hybrid education model to respond to the Great Commission. The Great Commission strongly emphasizes the value of training new disciples.
Albert Loho, Asti Maharini, Adi Bambang Wiwoho, Debby Margaret Tarore, May, Jonathan Gamaliel Gratia Loho, Markus Kusmanto, Moudy Eldy Kereh, Tolop Oloan Marbun   +8 more
doaj   +1 more source

Lion and The Unicorn [PDF]

, 2011
Exhibition 2-10 May 2011 to mark 60 years of RCA participation in post war UK design. Sponsored by Royal Commission for the Great Exhibition of 1851, Sandersins and Napier heritage Trust, RCA Gulbenkian Gallery Kensington Gore, Catalogue of exhibition ...
Curtis, Barry, Goodden, Henrietta, Pajaczkowska, Claire   +2 more
core  

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Exploring the use of satellite Earth observation active wildland fire hotspot data via open access web platforms

International Journal of Digital Earth
Globally, managing wildland fire is increasing in complexity. Satellite Earth Observation (EO) data, specifically active fire ‘hotspot’ data, is often used to inform wildland fire management.
Emily S. Hope, Colin B. McFayden, Mark C. de Jong, Morgan A. Crowley, Joshua M. Johnston, Diane K. Davies, Otmar Olsina, Jennifer Hewson, Jesús San-Miguel-Ayanz, Davide Ferrari, Meghan Sloane   +10 more
doaj   +1 more source

Is Matthew 28:16–20 the summary of the Gospel?

HTS Teologiese Studies/Theological Studies, 2014
It is generally acknowledged that the Great Commission at the end of Matthew’s Gospel is a dramatic and fitting end to the evangelist’s narrative. In the eyes of many scholars this final pericope does more than simply conclude the Gospel; it serves as a ...
David C. Sim
doaj   +1 more source

The Great Commission in Quadriphonic Sound

, 1992
As we explore the similarities and differences between the four Gospels in the freshman Bible class I teach, just about every semester one of my students will ask, \u27Why is the \u27Great Commission\u27 mentioned in all four Gospels?
Anderson, Paul N.
core  

Evaluation of the Efficacy and Safety of Satralizumab in a Pregnant NMOSD Patient With AQP4/MOG‐IgG Dual Seropositive: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Neuromyelitis Optica Spectrum Disorder (NMOSD) is a chronic autoimmune neuroinflammatory disease, typically characterized by antibodies against aquaporin 4 (AQP4‐IgG) or myelin oligodendrocyte glycoprotein (MOG‐IgG). Simultaneous seropositivity for both antibodies in a single patient is exceedingly rare.
Yeting Luo, Shuhua Xie, Xianghong Liu
wiley   +1 more source