Results 81 to 90 of about 4,134,359 (305)

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

open access: yesAdvanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying   +8 more
wiley   +1 more source

Stamping Lithography on Arbitrary Surfaces based on Self‐Assembly of Colloidal Particles

open access: yesAdvanced Science, EarlyView.
A new method called Stamping Lithography for three‐dimensional (3D) circuits manufacturing is proposed, which comprises a resist mask stamping process based on self‐assembly of colloidal particles and a subsequent etching process. It replaces the photoresist with self‐assembled particles and the exposure process with stamping, making it feasible to ...
Guoxu Yu   +8 more
wiley   +1 more source

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

open access: yesAdvanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai   +12 more
wiley   +1 more source

Bidirectionally Thermochromic Nanocolloid System for on‐Demand Optical Switching and Agricultural Energy Management

open access: yesAdvanced Science, EarlyView.
A bidirectionally thermochromic nanocolloid system is developed for facility agriculture. The bidirectional and wide‐temperature response dynamically modulates light radiation, stabilizing the indoor climate, improving supplemental lighting efficiency, and accelerating plant photosynthesis.
Qinbo Jiang, Jiayi Li, Hui Zhang
wiley   +1 more source

Der Einfluss von personeller Einkommensverteilung auf die „Great Depression“ und die „Great Recession“

open access: yesMomentum Quarterly, 2015
Der Einfluss gestiegener Einkommensungleichheit auf die „Great Depression“ und die „Great Recession“ wurde mehrfach postuliert (Galbraith 1954/2009; Eccles 1951; Rajan 2010; Stiglitz 2012; Piketty 2014).
Stefan Trappl
doaj   +2 more sources

Enhanced Responsivity, Accuracy, and Stability of Aerosol Jet Printing via Mechanical Switching Valve Assisted Internal Shuttering

open access: yesAdvanced Science, EarlyView.
This work demonstrates ultra‐high ON‐OFF responsivity of AJP by mechanical switching valve assisted shuttering. The jet relaxation and ON‐OFF delay are substantially eliminated from greater than 35 s, maintaining patterning quality independent of the variations of printing parameters, permitting excellent process stability and universality.
Jinhang Wang   +6 more
wiley   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

open access: yesAdvanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li   +9 more
wiley   +1 more source

Record‐High Latent Heat, Ultra‐Fast Relaxation and Closed‐Loop Recycling Double‐Brush Polymer Networks for Self‐Adaptive Thermal Interface Management

open access: yesAdvanced Science, EarlyView.
By grafting dense long double‐brush chains, we synthesized bottlebrush networks with high theoretical enthalpy. Their low entanglement, combined with dynamic bonds, promotes crystalline domain reorganization and minimizes enthalpy loss, achieving a record enthalpy of 240.7 J·g−1.
Qiguang Liu   +7 more
wiley   +1 more source

Single‐Crystal PZT‐Driven Organic Piezo‐Phototronic Adaptive Transistors Toward Advanced Spatiotemporal Visual Computing

open access: yesAdvanced Science, EarlyView.
Here, we propose a single‐crystal PZT‐based piezo‐phototronic organic adaptive memory transistor (OAMT), achieving a record memory window capacity factor (γ) of 0.87 at a low SS of 200 mV/decade via efficient multi‐field control. The device achieves a high recognition accuracy ∼ 90% in neuromorphic simulations, demonstrates robust fault tolerance under
Chenhao Xu   +8 more
wiley   +1 more source

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