Results 31 to 40 of about 172,325 (255)
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Do Expectations Matter? The Great Moderation Revisited [PDF]
SSRN Electronic Journal, 2008 We examine the role of expectations in the Great Moderation episode. We derive theoretical restrictions in a New-Keynesian model and test them using measures of expectations obtained from survey data, the Greenbook and bond markets. Expectations explain the dynamics of inflation and interest rates but their importance is roughly unchanged over time ...
Canova, Fabio, Gambetti, Luca
openaire +9 more sources
Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies
FEBS Open Bio, EarlyView.Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa +13 more
wiley +1 more source
The great moderation: updated evidence with joint tests for multiple structural changes in variance and persistence [PDF]
, 2019 We assess the empirical evidence about the Great Moderation using a comprehensive framework to test for multiple structural changes in the coefficients and in the variance of the error term of a linear regression model provided by Perron, Yamamoto, and ...
Perron, Pierre, Yamamoto, Yohei
core
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Introduction Many artificial intelligence (AI) solutions have been proposed to enhance the radiotherapy (RT) workflow, but limited applications have been implemented to date, suggesting an implementation gap. One contributing factor to this gap is a misalignment between AI systems and their users.
Luca M. Heising +11 more
wiley +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Background The use of deep learning‐based auto‐contouring algorithms in various treatment planning services is increasingly common. There is a notable deficit of commercially or publicly available models trained on large or diverse datasets containing high‐dose‐rate (HDR) brachytherapy treatment scans, leading to poor performance on images ...
Andrew J. Krupien +8 more
wiley +1 more source
Stock Market Volatility and the Great Moderation [PDF]
Finance and Economics Discussion Series, 2005 Using data on corporate profits forecasts from the Survey of Professional Forecasters, I decompose real stock returns into a fundamental news component and a return news component and analyze the effects of the Great Moderation on each. Empirically, the response of each component of real stock returns to the Great Moderation has been quite different ...
openaire +3 more sources
Energy dependence of the GAFCHROMIC LD‐V1 in the diagnostic radiographic modalities
Journal of Applied Clinical Medical Physics, EarlyView.Abstract The GAFCHROMIC LD‐V1 radiochromic film is widely used in dosimetry because it can provide high‐resolution two‐dimensional dose distributions without processing. This study aimed to evaluate the response characteristics at different effective energies, from the low‐energy range of mammography to the high‐energy range of computed tomography. Net
Tatsuhiro Gotanda +9 more
wiley +1 more source
High-Growth Recoveries, Inventories and the Great Moderation [PDF]
SSRN Electronic Journal, 2009 We present evidence about the disappearance of the high-growth recoveries from recessions with intense job creation typically observed until the eighties. This result matches the belief that recessions now have an L-shape as opposed to the old-time recessions that always had a V-shape. We also show how this change in business cycle dynamics can explain
Maximo Camacho +4 more
openaire +6 more sources
The Impact of Diabetes and Metabolic Syndrome Burden on Pain, Neuropathy Severity and Fiber Type
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Determine the association between diabetes and metabolic syndrome (MetS) burden (number of MetS criteria fulfilled) and pain, neuropathy severity, and fiber type involvement in individuals with established polyneuropathy. Methods The Peripheral Neuropathy Research Registry was queried for individuals with type 1 and type 2 diabetes ...
Long Davalos +13 more
wiley +1 more source