Results 31 to 40 of about 10,035 (178)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Association of duplex ultrasonography findings with the severity of chronic venous disease in Thai patients

Asian Journal of Surgery, 2023
Introduction: Chronic venous disease (CVD) is characterized by venous hypertension and stasis, which occur because of valvular incompetence and/or venous outflow obstruction.
Nawaphan Taengsakul
doaj   +1 more source

The Cutaneous Branch of the Obturator Nerve: Common Finding or a Rarity Worthy of Note

Clinical Anatomy, EarlyView.
ABSTRACT According to textbook descriptions, branches of the femoral and obturator nerves provide the sensory innervation to the medial side of the thigh. However, as the exact prevalence of the obturator nerve's cutaneous branch is unknown, an anatomic study was conducted to reveal its role in providing cutaneous innervation to the medial thigh ...
Christoph Fuchssteiner, Theresia Stigger, Gerlinde M. Gruber, Peter. C. Brugger   +3 more
wiley   +1 more source

Saphenous vein dilation as an alternative to prosthetic femoral–distal bypass revascularization

Journal of Vascular Surgery Cases and Innovative Techniques, 2022
A 63-year-old man with a history of bipolar and schizoaffective disorder was admitted to the psychiatry unit. His comorbidities included active smoking, hypertension, diabetes, hyperlipidemia, coronary artery disease after coronary artery bypass grafting,
Eric J. Maldonado, MD, Kaspar Trocha, MD, David J. Finlay, MD, FACS, RPVI   +2 more
doaj   +1 more source

Same site recurrence following standardized high ligation and stripping of the great saphenous vein – 5‐year results of the LaVaCro trial

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Same‐site recurrence at the sapheno‐femoral junction (SFJ) takes up a large amount of the daily practice of phlebologists. Follow‐up data for high‐ligation and stripping (HL/S) of the great saphenous vein (GSV) are quite heterogenous and incoherent.
Thomas Hummel, Georgios Papapostolou, Margit Broermann, Christoph Dresler, Ingo Flessenkämper, Michael Jünger, Dietmar Stenger, Dominic Mühlberger, Yazad Sidhwa, Thomas Falkenstein, Markus Stücker, Achim Mumme   +11 more
wiley   +1 more source

Intraoperative Analysis of Flow Dynamics in Arteriovenous Composite Y Grafts

Brazilian Journal of Cardiovascular Surgery
Objective: Composite graft of left internal thoracic artery and great saphenous vein in revascularization of the left coronary system is a technique well described in literature.
Heraldo Guedis Lobo Filho, José Glauco Lobo Filho, Matheus Duarte Pimentel, Bruno Gadelha Bezerra Silva, Camylla Santos de Souza, Marília Leitão Montenegro, Maria Cláudia de Azevedo Leitão, Francisco Vagnaldo Fechine Jamacuru   +7 more
doaj   +1 more source

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant, Ingeborg M. van Geijlswijk, Mathias Devreese, Marc Cherlet, Leo F. van Geest, Jaap A. Wagenaar, Jan A. M. Langermans, Aldert L. Zomer, Jaco Bakker, Ronette Gehring   +9 more
wiley   +1 more source

Endoscopic vein harvesting in coronary artery bypass grafting

Zhongguo linchuang yanjiu
Objective To evaluate the early clinical effect of the application of endoscopy in coronary artery bypass grafting to obtain the great saphenous vein.
XU Can, PAN Jun, ZHOU Qing, WANG Dongjin
doaj   +1 more source

Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertension

Experimental Physiology, EarlyView.
Abstract Menopause increases the risk of hypertension in women, yet the factors contributing to this important change remain unclear. Because early life stress has persistent and sex‐specific consequences on health, we hypothesized that ageing reveals the latent effects of neonatal maternal separation (NMS) on cardiovascular homeostasis in female rats.
Danuzia Ambrozio‐Marques, Loralie Mei Guay, Alicia A. Koogler, Tim D. Ostrowski, Aline M. Arlindo de Souza, Kathryn Sandberg, Richard Kinkead   +6 more
wiley   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source