Results 191 to 200 of about 120,010 (292)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Computer aided greenness by design approach for resolving and quantifying Triamterene and Hydrochlorothiazide in pharmaceutical mixtures employing multiscale dynamics simulations. [PDF]

Sci Rep
Elsonbaty A, Attala K, Darweish E.
europepmc   +1 more source

A Second Chance for Expired Medication: Teaching Green Analytical Chemistry in an Analytical Chemistry Laboratory Course for Undergraduate Students

Alessandro Streuli, Vanessa Erckes, Christian Steuer   +2 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Dual-emission nitrogen-doped carbon dots for ratiometric and smartphone-based detection of levofloxacin. [PDF]

RSC Adv
Abubakr SA, Mohammed SJ, Alshatteri AH.
europepmc   +1 more source

Sustainable method development: Applying Analytical Quality by Design and comprehensive green chemistry principles in the HILIC method for caffeine and paracetamol analysis

Darija Knežević Ratković, Irena Kasagić‐Vujanović   +1 more
openalex   +1 more source

Applying green analytical chemistry for rapid analysis of drugs: Adding health to pharmaceutical industry

, 2012
Nazrul Haq, Muzaffar Iqbal, Fars K. Alanazi, Ibrahim A. Alsarra, Faiyaz Shakeel   +4 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Green UHPLC approach for the quantitative determination of tiopronin residues in cleaning validation processes. [PDF]

BMC Chem
Gohel J, Patel A, Kotadiya R.
europepmc   +1 more source

Green Analytical Chemistry: A Comprehensive Review of Eco-Scale, Greenness Metrics, and Sustainability Approaches

T. Rama Rao, Dr Afreen, Srilaxmi Battula
openalex   +1 more source