Results 151 to 160 of about 15,091,607 (309)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Strategies of CFSM Green Circular Development Research in the Qinba Mountain Area [PDF]
, 2016 Liu Xu +3 more
openalex +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Delineation of site-specific management zones to enhance nutrient status, growth, and quality of green onion (Allium cepa L.) in a newly reclaimed area in Ismailia, Egypt [PDF]
Abdelraouf M. Ali +8 more
openalex +1 more source
Features of the Common Myna in Green Areas of Almaty [PDF]
, 2019 Yeszhanov Birlikbay +5 more
openalex +1 more source
Pursuing Green Growth: Some Conflicts and Necessary Conditions for a Pragmatic Environmental Policy [PDF]
This paper focusses narrowly on three areas of public policy concerning the environment deemed necessary for sustainable economic growth. It has relevance to Asian nations as they continue to demand for higher growth and at the same time keeping ...
Euston Quah
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Lighting of urban green areas – the case of Grabiszyn Park in Wrocław. Searching for the balance between light and darkness through social and technical issues [PDF]
, 2019 Agata Łopuszyńska +1 more
openalex +1 more source