Results 201 to 210 of about 315,719 (255)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Oxygen Attachment Dissociation of Protonated Reserpine and Its Analogs. [PDF]

Rapid Commun Mass Spectrom
Li JG, Bowen CJ, Chan B, Stewart AWE, Takahashi H, O'Hair RAJ.   +5 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

In Silico Studies of Potent Tyrosine Kinase Inhibitors: Molecular Docking and Pharmacophore Modeling Approaches. [PDF]

Molecules
Mavridis E, Pontiki E, Hadjipavlou-Litina D.   +2 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Phytochemical-mediated green synthesis of selenium nanoparticles using Catharanthus roseus and their physicochemical characterization, biological evaluation, and molecular docking analysis. [PDF]

Sci Rep
Desouky AF, Fahim AM, Kelany AK, Kamel MA, Mohamed AF, Abo Elsoud MM, Abdelhamid SA.   +6 more
europepmc   +1 more source

Molecular modeling of highly selective CDK1 Inhibitors based on pyrazolo-pyrimidines using 3D-QSAR, docking, and molecular dynamics simulations. [PDF]

PLoS One
Tahir MA, Chohan TA, Qayyum A, Yahya Abdullah Alzahrani A, R Alzahrani A, Ur Rehman Z, Khan A, Ashfaq K.   +7 more
europepmc   +1 more source

A unified strategy for remote C-H fluorination of phenylacetic acids and their homologues at the <i>meta</i>-position. [PDF]

Chem Sci
Zhou K, Chen X, Wang Y, Mao YJ, Yang X, Liu K, Pan Q, Pan DL, Xu DQ, Lou SJ.   +9 more
europepmc   +1 more source

Lid loop-mediated proton transfer revealed in the Fe/αKG-dependent decarboxylase TraH. [PDF]

Commun Chem
Zheng X, Ge R, Guo Z, Girbig M, Freitag J, Li A, Hochberg GKA, Li SM, Bange G, Zheng L.   +9 more
europepmc   +1 more source

Highly Active CH Bond Borylation of Aromatics With Pyridine as Convenient, Low-Cost Ligand Under Iridium Catalysis. [PDF]

ChemSusChem
Delahaye V, Roisnel T, Dérien S, Achard M, Gramage-Doria R.   +4 more
europepmc   +1 more source