Results 111 to 120 of about 3,334,849 (290)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Simon Dow in rehearsal for 'La Boheme', West Australian Ballet, 2004 [picture] /
, 2004 Part of collection: Jon Green collection of photographs of Australian dancers and choreographers.; Title supplied by photographer.; Image from Jon Green's private collection, 'Avec attitude'.; Acquired in digital format; access copy available online ...
Green, Jon.
core
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Selective RGB Channel Jittering for Robust Endoscopic Disease Detection Across Multiple Lesion Types
Sakarya University Journal of Computer and Information SciencesDeep learning has significantly advanced medical image analysis, particularly in the field of endoscopic images. However, these advancements are constrained by the availability of high-quality, annotated medical datasets.
Duygu Cakır
doaj +1 more source
Callum Hastie of West Australian Ballet, April 2004 [picture] /
, 2004 Part of collection: Jon Green collection of photographs of Australian dancers and choreographers.; Title supplied by photographer.; Image from Jon Green's private collection 'avec attitude'.; Acquired in digital format; access copy available online ...
Green, Jon.
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
SESAR 3 ER 1 Green-GEAR – D5.1 – Initial OSED – Green RC
Green-GEAR aims at enabling and incentivising optimum green trajectories and airspace use through new ATM procedures; it develops three new SESAR Solutions to this end.
Bolic, T.
core +3 more sources
Impact of improved stroke green channel process on the delay of intravenous thrombolysis in patients with acute cerebral infarction during the COVID-19 pandemic: An observational study. [PDF]
Front Neurol, 2022 Wang Q +5 more
europepmc +1 more source