Results 61 to 70 of about 856,223 (304)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

AI‐Driven Deep Learning Framework for Detecting Subtle Surface Defects on Wind Turbine Blades

Wind Energy
Wind turbine blade surface defect detection is of great significance in ensuring the safety and operational efficiency of wind power systems. However, accurately detecting subtle and small‐scale defects remains challenging under complex imaging ...
Shoutu Li, Jiawei Pan, Ling Liu, Jin Zhao, Nianxi Yue, Zhen Wu   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Intermetallic Pd3X (X= Ti and Zr) nanocrystals for electro-oxidation of alcohols and formic acid in alkaline and acidic media

Science and Technology of Advanced Materials, 2020
Two highly active and stable Pd-based intermetallic nanocrystals with early d-metals Pd3Ti and Pd3Zr have been developed. The nanocrystals are synthesized by co-reduction of the respective salts of Pd and Ti/Zr.
Rajesh Kodiyath, Gubbala V. Ramesh, Maidhily Manikandan, Shigenori Ueda, Takeshi Fujita, Hideki Abe   +5 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Safe UAV Control Against Wind Disturbances via Demonstration-Guided Reinforcement Learning

Drones
Unmanned Aerial Vehicle (UAV) operating in complex environments require guaranteed safety mechanisms while maintaining high performance. This study addresses the challenge of ensuring strict flight safety during policy execution by implementing a Control
Yan-Hao Huang, En-Jui Liu, Bo-Cing Wu, Yong-Jie Ning   +3 more
doaj   +1 more source

Thermal responses and comfortable evaluations under variable dynamic environment: A case study of MAV [PDF]

E3S Web of Conferences
With the improvement of living standards, the requirements of occupants tend to be diverse. A representative adaptive strategy of variable dynamic ventilation, Multi-vent module-based adaptive ventilation (MAV), is regarded as the research object ...
Zhang Weijia, Zhang Weirong, Zhang Haotian, Xuan Yingli, Qing Zhixi, Ding Xiaoxiao   +5 more
doaj   +1 more source

Acknowledgement to Reviewers of Green Energy and Sustainability [PDF]

, 2022
Constantinos A. Balaras
openalex   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Shuffled Puma Optimizer for Parameter Extraction and Sensitivity Analysis in Photovoltaic Models

Energies
Photovoltaic (PV) systems are the core technology for implementing net-zero carbon emissions by 2050. The performance of PV systems is strongly influenced by environmental factors, including irradiance, temperature, and shading, which makes it difficult ...
En-Jui Liu, Rou-Wen Chen, Qing-An Wang, Wan-Ling Lu   +3 more
doaj   +1 more source