Results 61 to 70 of about 724,730 (341)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Can Land Finance Support the Improvement of Urban Green Space: Based on Moderating Effect of Environmental Governance

Redai dili
To enhance ecological civilization, establishing a governance framework that reconciles the principles of financial sustainability with those of urban green development has been identified as an effective pathway for urban sustainability.
Wang Jie, Zhang Yuzhen, Luo Jiahao, Song Mengqiao   +3 more
doaj   +1 more source

Green finance: current status, development, and future course of actions in China

Environmental Research Communications, 2023
This study explores China’s implementation of a green financial system to combat the urgent climate emergency and achieve sustainable development amid rapid industrial and urban development.
Wenfang Feng, Pierre Bilivogui, Jichao Wu, Xiaoyang Mu   +3 more
doaj   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

An Overview of the Impact of Green Finance on Green Total Factor Productivity

Journal of Risk Analysis and Crisis Response (JRACR)
This paper discusses the impact of green finance on the green total factor productivity of enterprises, and aims to summarize and analyze the research dynamics, trends and key issues of green finance on green total factor productivity.
Meng-yao Zhan, Mu Zhang
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Green finance and green growth: do green technological innovation and financial constraints matter?

Cogent Economics & Finance
Green finance is an effective means to achieve both economic growth and ecological sustainability. Using Green Finance Reform and Innovation Pilot Zone policy in 2017, 2019 and 2022 as a quasi-natural experiment respectively, this study combines panel ...
Shengying Shi, Hamdan Al-Jaifi, Harpaljit Kaur   +2 more
doaj   +1 more source

“Green” Transportation Taxes and Fees: A Survey Of Californians, MTI Report 08-05 [PDF]

, 2009
This report explores public opinion on a new and promising concept—green transportation taxes and fees. These are taxes and fees set at variable rates, with higher rates for more polluting vehicles and lower rates for those that pollute less.
Agrawal, Asha Weinstein, Dill, Jennifer, Nixon, Hilary   +2 more
core   +1 more source