Results 51 to 60 of about 452,501 (259)

A Conceptual Approach to Reduce the Product Gas Crossover in Alkaline Electrolyzers

Membranes
The crossover of the product gases hydrogen and oxygen in alkaline electrolyzer operation is a critical factor, severely limiting the operational window in terms of current density and pressure.
Diogo Loureiro Martinho, Torsten Berning
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Coordinated Optimization of Intelligent Soft Open Points and Multiple Types of Shared Energy Storage in Distribution Networks Considering Flexibility Deficiency Risk

发电技术
ObjectivesTo address the operational security issues in the new-type distribution network caused by the high-penetration integration of renewable energy, this paper proposes a coordinated optimization method for intelligent soft open points and multiple ...
WANG Jie, XU Lijun, LI Xiaozhu, FAN Xiaochao, GULIZHATI∙Hailati, WANG Weiqing   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effects of a perpendicular ultrasonic field on planar and porous electrodes for hydrogen production in alkaline conditions

Ultrasonics Sonochemistry
Among water electrolysis systems, alkaline water electrolysers (AWE) are promising for large-scale hydrogen production due to their cost-effective nickel (Ni) electrodes.
Jérémy Gravelle, Vanessa Avramovic, Loïc Hallez, Jean-Yves Hihn, Bruno G. Pollet   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A highly active magnetic solid superbase catalyst for hydrocracking C-O bridged bonds of extraction residue from Huolinguole lignite

Applied Catalysis O: Open
A highly active magnetic solid superbase (MSS) catalyst, Mg2Si supported on Fe3O4@SiO2, was synthesized and characterized using transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX), vibrating sample magnetometry (VSM), X-ray
Weiwei Ma, Taoyuan Hao, Xinwang Song, Xia Liu   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Green hydrogen as a fuel

, 2022
Keys for its contribution to a decarbonised economy Hydrogen produced using renewable energies is expected to play an essential role in the energy transition towards a decarbonised economy by 2050. Although its current main use is as a raw material in industry, hydrogen is a highly versatile fuel, which opens the door to a wide range of new ...
openaire   +2 more sources