Results 51 to 60 of about 453,272 (259)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Hierarchical GA–LP Framework with Explainable AI and Clustering for Generating and Interpreting Diverse Feasible Solutions in Net-Zero Energy Systems: An Illustrative Case Study

Energies
The transition to net-zero energy systems involves substantial uncertainty in exogenous conditions such as policy, fuel prices, and technology deployment.
Ryosuke Gotoh, Wataru Sato, Yuuri Nagase, Tomohiro Mizukami   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Green Energy or Green Colonialism? The Case of Green Hydrogen in Namibia

Green hydrogen, promoted by institutions like the International Renewable Energy Agency and the European Union as pivotal to decarbonization, faces criticism through the lens of green colonialism. This paper argues that the energy transition often replicates neo-colonial resource extraction, particularly in Global South nations such as Namibia, where ...
Venditto B, Kamwanyah N. J
openaire   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Urea electrooxidation coupled with energy-saving H2 production using bimetallic sulfide heterojunctions

Electrochemistry Communications
The theoretical electrocatalytic potential for the urea oxidation reaction (UOR) is notably low at 0.37 V, positioning it as a promising alternative to hydrogen evolution reaction for traditional water electrolysis.
Suzhen Bai, Kesheng Cao, Yi Zeng, Zhengshan Tian, Xiangxiang Du, Xingqun Zheng   +5 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

An alkaline electrolyzer having a diaphragm surface coating to enable bubble formation and thus reduce the crossover rates of the product gases

Invention Disclosure
Alkaline electrolyzer technology is widely considered the most mature and cost-effective way of producing green hydrogen, provided the electricity to operate the electrolyzer is generated via renewable energies.
Torsten Berning, Diogo Loureiro Martinho
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Composite zeolite catalysts and catalyst grading technology for high-efficiency hydrocracking of 1-methylnaphthalene to BTX

Fuel Processing Technology
Hydrocracking of polycyclic aromatic hydrocarbons (PAHs) to produce benzene, toluene, and xylene (BTX) represents an effective route for upgrading light cycle oil (LCO).
Zunlong Hu, Denglei Gao, Huanrong Liu, Qingyang Li, Linjie Wang, Xiaofei Zhang, Haodong Xie, Yuhan He, Xiulin Wang, Changjian Liu, Zhijie Wu   +10 more
doaj   +1 more source