Results 51 to 60 of about 2,665,379 (240)
Hydrogen production potential in Nigeria
, 2023 Today, the Nigerian economy is highly dependent on the export of fossil fuels. At the same time, the country has large renewable energy resources. With the help of low-emission hydrogen, Nigeria can transition its own energy supply and exports to a ...
Prieß, Tobias +2 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Green Map Flushing Meadow Queens NY
, 2005 A map of Flushing Meadows Corona Park in Queens, NY, site of two world fairs (1939 and 1964) currently home to a number of recreation facilities and green space.
Green Map System (Firm)
core +1 more source
DFT computational insight into the catalytic dehydrogenation of formic acid for H2 production over Cr-doped C20 fullerene: Cr–H active center and high selectivity mechanism [PDF]
RSC AdvancesThe dehydrogenation of formic acid (HCOOH) to H2 offers a sustainable energy conversion route, yet developing efficient non-noble metal catalysts remains a critical challenge.
Jihong Xu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
, 2022 Keys for its contribution to a decarbonised economy Hydrogen produced using renewable energies is expected to play an essential role in the energy transition towards a decarbonised economy by 2050. Although its current main use is as a raw material in industry, hydrogen is a highly versatile fuel, which opens the door to a wide range of new ...
openaire +2 more sources
A Conceptual Approach to Reduce the Product Gas Crossover in Alkaline Electrolyzers
MembranesThe crossover of the product gases hydrogen and oxygen in alkaline electrolyzer operation is a critical factor, severely limiting the operational window in terms of current density and pressure.
Diogo Loureiro Martinho, Torsten Berning
doaj +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source