Results 61 to 70 of about 2,994,761 (283)

DFT computational insight into the catalytic dehydrogenation of formic acid for H2 production over Cr-doped C20 fullerene: Cr–H active center and high selectivity mechanism [PDF]

RSC Advances
The dehydrogenation of formic acid (HCOOH) to H2 offers a sustainable energy conversion route, yet developing efficient non-noble metal catalysts remains a critical challenge.
Jihong Xu, Aili Feng, Shiling Yuan, Hongjun Zhou, Dongju Zhang   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Coordinated Optimization of Intelligent Soft Open Points and Multiple Types of Shared Energy Storage in Distribution Networks Considering Flexibility Deficiency Risk

发电技术
ObjectivesTo address the operational security issues in the new-type distribution network caused by the high-penetration integration of renewable energy, this paper proposes a coordinated optimization method for intelligent soft open points and multiple ...
WANG Jie, XU Lijun, LI Xiaozhu, FAN Xiaochao, GULIZHATI∙Hailati, WANG Weiqing   +5 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Green hydrogen as a fuel

, 2022
Keys for its contribution to a decarbonised economy Hydrogen produced using renewable energies is expected to play an essential role in the energy transition towards a decarbonised economy by 2050. Although its current main use is as a raw material in industry, hydrogen is a highly versatile fuel, which opens the door to a wide range of new ...
openaire   +2 more sources

A Conceptual Approach to Reduce the Product Gas Crossover in Alkaline Electrolyzers

Membranes
The crossover of the product gases hydrogen and oxygen in alkaline electrolyzer operation is a critical factor, severely limiting the operational window in terms of current density and pressure.
Diogo Loureiro Martinho, Torsten Berning
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Effects of a perpendicular ultrasonic field on planar and porous electrodes for hydrogen production in alkaline conditions

Ultrasonics Sonochemistry
Among water electrolysis systems, alkaline water electrolysers (AWE) are promising for large-scale hydrogen production due to their cost-effective nickel (Ni) electrodes.
Jérémy Gravelle, Vanessa Avramovic, Loïc Hallez, Jean-Yves Hihn, Bruno G. Pollet   +4 more
doaj   +1 more source