Results 91 to 100 of about 4,413,920 (355)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Do innovation policies and fintech create synergistic effects for the sustainability of urban green innovation?

Sustainable Futures
In light of the increasing global emphasis on environmental sustainability, it is essential to comprehend the synergies between innovation policies and financial technologies in promoting sustainable green innovation.This paper examines the synergistic ...
Cunlin Li, Shiyu Zhang
doaj   +1 more source

Green growth, technology and innovation [PDF]

The paper explores existing patterns of green innovation and presents an overview of green innovation policies for developing countries. The key findings from the empirical analysis are: (1) frontier green innovations are concentrated in high-income ...
Dutz, Mark A., Sharma, Siddharth
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Innovating a Green Real Deal [PDF]

Science, 2019
As the United States heads toward an election year in 2020, climate change promises to stay in the headlines. Increasing public concern about and desire to address the consequences of global warming drive this attention, along with the debate about a Green New Deal that promotes social justice alongside accelerated deep reductions in greenhouse gas ...
openaire   +2 more sources

Digital transformation and corporate green innovation: An affordance theory perspective

Business Strategy and the Environment
The rise of cutting‐edge technologies motivates corporations to undertake and carry forward green innovation, aiding economic development by maintaining environmental sustainability.
Zhe Sun, Liang Zhao, Ankit Mehrotra, M. Salam, M. Yaqub   +4 more
semanticscholar   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Mapping the knowledge of green innovation: a systematic literature review [PDF]

Journal of Humanities and Applied Social Sciences
Purpose – Green innovations (GI) is an emerging field that presents an opportunity to thrive in the competitive market. Nevertheless, in the field of green innovation, there is no clear and complete picture.
L.R. Rupasinghe, M.D. Pushpakumari, G.D.N. Perera   +2 more
doaj   +1 more source

Digital capability and green innovation: The perspective of green supply chain collaboration and top management's environmental awareness

Heliyon
The emergence of the digital economy has accelerated digital transformation, and digitalization has shown new potential and solutions to increasingly severe environmental challenges.
Wen Cheng, Qian Li, Qunqi Wu, Fei Ye, Yahong Jiang   +4 more
semanticscholar   +1 more source