Results 241 to 250 of about 503,070 (300)

Ultra‐High‐Throughput Discovery of Multifunctional Polyphenolic Coatings on Droplet Microarrays

Advanced Materials, EarlyView.
An ultra‐high‐throughput (UHT) combinatorial strategy enables the miniaturized synthesis and screening of ≈30 000 polyamine‐polyphenolic (PaPp) coatings using droplet microarrays (DMA). This approach reveals hundreds of previously unknown fluorescent, redox‐active, and antibacterial materials, including multifunctional, cell‐compatible surfaces ...
Vania Tanda Widyaya, Joaquín E. Urrutia Gómez, Paul Reuß, Alexander Welle, Rolf A. Gattung, Jana Mayer, Peter Krolla, Markus Reischl, Pascal Friederich, Anna A. Popova, Thomas Schwartz, Pavel A. Levkin   +11 more
wiley   +1 more source

AI-Augmented Iterative Screening of Libraries Against RNA Targets (AISLAR) Boosts Discovery of SAR-Tractable RNA Binders and Rational Analog Design. [PDF]

Small Sci
Hattori H, Otsu M, Imai K, Narahara M, Kondo J, Shino A, Morishita EC.   +6 more
europepmc   +1 more source

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

A high-throughput screening platform to facilitate treatment development in Rett syndrome. [PDF]

Front Neurol
Yin Y, Wang A, Dong Q, Zhang Z, Bu Q, Wang R, Chang Q.   +6 more
europepmc   +1 more source

Combination of 3D and 2D Small and Wide Angle X‐Ray Scattering Imaging Reveals Diminished Bone Quality in the Superior Human Femoral Neck Cortex

Advanced Materials, EarlyView.
Combined 2D and 3D X‐ray scattering imaging is used to analyse nanostructural properties in the inferior and superior cortex of 78 human femoral necks from 44 donors. The methodology allows for increased interpretation of nanostructure in a statistically relevant dataset, revealing nanostructural differences in anatomical locations critical to clinical
Torne Tänzer, Tatiana Kochetkova, Arthur Baroni, Mathieu Simon, Mads Carlsen, Santiago Fernandez Bordin, Manuel Guizar‐Sicairos, Philippe Zysset, Marianne Liebi   +8 more
wiley   +1 more source

Disulfide tethering reveals cryptic pockets in oncogenic KRAS. [PDF]

Commun Chem
Balius TE, Dyba M, Kumari V, Denson JP, Yi M, Sharma AK, Prakash P, Alberico E, Messing S, Wall V, Chan AH, Simanshu DK, Nissley DV, McCormick F, Esposito D, Maciag AE, Turner DM.   +16 more
europepmc   +1 more source

IR Spectroscopy and Linear Support Vector Machine Analysis of Colorectal Liver Metastasis. [PDF]

J Phys Chem B
Coe JV, Allen HC, Skarda SA, Orr TD, Wilson Ii AL, Wilson DG, Kalliantas S, Nystrom SV, Bradley RC, Li R, Chen Z, Hitchcock CL, Martin EW.   +12 more
europepmc   +1 more source

Efficient Method for High-Throughput Screening of Compound Libraries Targeting Human PD-L1. [PDF]

ACS Omega
Zamani MR, Čermáková K, Hadzima M, Šácha P, Konvalinka J.   +4 more
europepmc   +1 more source

Seven complete comparative maps of allosteric mutations in a protein family. [PDF]

Nat Commun
Martí-Aranda A, Lehner B.
europepmc   +1 more source

Utilizing drugs, food, and natural product libraries: A computational approach to targeting PGAM1 in clinical cancer therapy. [PDF]

Medicine (Baltimore)
Alanzi AR, Alharbi HA.
europepmc   +1 more source