Results 111 to 120 of about 4,065,582 (286)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Lattice-Based Decision Models for Green Urban Development: Insights from $$L_{q}*$$ L q ∗ q-Rung Orthopair Multi-fuzzy Soft Set

International Journal of Computational Intelligence Systems
Location selection is a critical process in decision-making for projects that involve multiple criteria, such as urban planning, industrial site development, or green building projects.
Vimala Jayakumar, Mahalakshmi Pethaperumal, Nasreen Kausar, Dragan Pamucar, Vladimir Simic, Mohammed Abdullah Salman   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Why matrices matter: investigating dye quantification in listerine® with UV-Visible spectroscopy

Emergent Scientist
While numerous studies have explored the quantification of compounds using UV-Visible absorption spectroscopy, matrix effects are rarely studied. This work, investigates the influence of matrix effects on the spectrophotometric determination of two dyes (
Taralle Charline, Breuilly Lou, Adam Sherin, Moccelin Fantine, Marin–Alemanni Clara, Méallet Rachel, Piard Jonathan   +6 more
doaj   +1 more source

Melissa Aurisch of West Australian Ballet, November 2003 [picture] /

, 2004
Part of collection: Jon Green collection of photographs of Australian dancers and choreographers.; Title supplied by photographer.; Image from Jon Green's private collection 'avec attitude'.; Acquired in digital format; access copy available online ...
Green, Jon.
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Patch size and vegetation condition influence surface-temperature contrasts around urban green patches in a humid subtropical city

Discover Cities
Urban regions in the humid subtropics are undergoing rapid land conversion, vegetation loss and intensifying heat exposure. Yet patch-level evidence for urban green-space cooling remains limited.
Satyabhan Singh, Priya Verma, Soumit Kumar Behera, Alka Kumari, Dibyendu Adhikari   +4 more
doaj   +1 more source

Emiliana Lione of West Australian Ballet, March 2004 [picture] /

, 2004
Part of collection: Jon Green collection of photographs of Australian dancers and choreographers.; Title supplied by photographer.; Image from Jon Green's private collection 'avec attitude'.; Acquired in digital format; access copy available online ...
Green, Jon.
core  

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source