Results 101 to 110 of about 1,602,420 (310)

Inclusive growth in English cities: mainstreamed or sidelined? [PDF]

open access: yes, 2018
The concept of inclusive growth is increasingly presented as offering prospects for more equitable social outcomes. However, inclusive growth is subject to a variety of interpretations and lacks definitional clarity.
Anne E. Green   +21 more
core   +3 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Optical coherence tomography (OCT)‐derived retina measurements are markers for neuroaxonal visual pathway status. High‐quality OCT scans are essential for reliable measurements, but their acquisition is particularly challenging in eyes with severe visual impairment, as often observed in neuromyelitis optica spectrum disorders ...
Hadi Salih   +40 more
wiley   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein   +7 more
wiley   +1 more source

Vom "Green New Deal" zum "European Green Deal"

open access: yes, 2020
New Deal: Einzelne Autoren und Institute, einige Regierungen und die Vereinten Nationen haben die Wiederbelebung und das Ergrünen eines alten Begriffs propagiert - Green New Deal. Um was es dabei geht oder gehen sollte, war aber höchst heterogen. Mit der Vorlage des Konzepts eines "European Green Deal" seitens der EU-Kommission im Dezember 2019 ist ...
openaire   +1 more source

New New Deals: Reforming Welfare Again? [PDF]

open access: yes, 2010
In both the Unites States and the United Kingdom, the idea of the New Deal has proved a potent political symbol during this crisis. In what follows, I explore some of the ways in which the imagery of the New Deal has been deployed and consider some of ...
Clarke, John
core  

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann   +17 more
wiley   +1 more source

A Science-Based Ecosocialist Strategy for Climate Security

open access: yesJournal of World-Systems Research
The natural, physical, and informational sciences—in particular, climatology, ecology, biogeochemistry, and thermodynamics—which along with the wisdom derived from the experience of thousands of years of indigenous peoples’ agriculture and culture ...
David Schwartzman
doaj   +1 more source

Development of a Personalized Visualization and Analysis Tool to Improve Clinical Care in Complex Multisystem Diseases With Application to Scleroderma

open access: yesArthritis Care &Research, EarlyView.
Objective In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently, and at the point of care. Methods We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of the trajectory of a ...
Ji Soo Kim   +18 more
wiley   +1 more source

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