Results 51 to 60 of about 20,318,182 (304)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The European Green Deal: New Opportunities for Port Cities?
, 2020 With the European Green Deal made public last December, the new European Commission took the first steps to transforming Europe into the first climate neutral continent by 2050.
Hauser, S.J. (author)
core
Domestic UK retrofit challenge: Barriers, incentives and current performance leading into the green deal [PDF]
, 2012 Copyright @ 2012 Elsevier - The official published version can be accessed from the link below.This paper reviews the thermal performance of the existing UK housing stock, the main fabric efficiency incentive schemes and the barriers to obtaining deep ...
Dowson, M +3 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
EchoGéo, 2009 This third article mainly based on the images of the inauguration ceremony (January 20th), on the president Obama’s discourse and on a few comments made by the media, describes the feeling of happiness and prideness as expressed by the American people on
Cynthia Ghorra-Gobin
doaj +1 more source
, 1979 The Roar is the New Deal High School yearbook.This issue was digitized in collaboration with the New Deal School ...
New Deal School District
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Financing a Green New Deal [PDF]
Joule, 2020 The Great Depression galvanized the New Deal in the United States to recover the economy, relieve the poor and unemployed, and reform the financial backbone of the country. Today, the impending adverse effects of climate change have governments proposing analogous Green New Deals.
openaire +1 more source