Results 61 to 70 of about 578,679 (264)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

THE THEORY OF SPACE CONCEPTS RELATED TO FORMULA GREEN OPEN SPACE

Journal of architecture&ENVIRONMENT, 2014
The concept of green open space is still stuck on the concept of space-based theory of absolute space by Issac Newton, who see space as a separation between the mass of the building as a container (solid) and open space (void). Meanwhile, the demands of the world's cities today to combine city life with the natural environment in the city increasingly ...
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The impact of noise on green open space value

Journal of Environmental Management
I investigate the effect of noise on the amenity value of urban green open spaces in Prague, Czech Republic. First, I use standard hedonic pricing model exploiting cross-sectional and quasi-experimental variation in the apartment price data and then I analyse green open spaces quality inferred from a quantitative spatial model.
openaire   +2 more sources

Healing Garden as a Green Open Space in Hospital

International Islamic Medical Journal
Introduction: Natural environments within healthcare settings have received growing interest for their potential role in supporting health and well-being. Healing gardens are typically green open spaces within hospitals that promote the physical, mental, and emotional rehabilitation of patients, also benefiting the staff and visitors.
Marselli Widya Lestari, Anisgupta Larasaty Favurita   +1 more
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

MANAGEMENT OF GREEN OPEN SPACE GREEN OPEN SPACE MANAGEMENT ON THE MAKASSAR CITY INDEPENDENCE PIONEER ROAD CORRIDOR

 Abstract This research aims to develop principles, develop innovations, and develop these in the arrangement of green open spaces. The type of research used is qualitative and descriptive quantitative research. In this study, the condition of the road median and the level of tree/plant damage were measured directly, while the community's aspirations ...
Giska Putri Lestari, Arifuddin Akil, Andi Bachtiar Arief   +2 more
openaire   +2 more sources

Surakarta’s Green Open Spaces: An Exploration of Their Biodiversity

IOP Conference Series: Earth and Environmental Science
Abstract Surakarta, also known as Solo, is strategically located to serve as a center of national activities. It is a key region of Central Java Province and forms part of the Joglosemar (Yogyakarta-Solo-Semarang) economic triangle. These factors have led to changes in land use for infrastructure development. As a
Okid Parama Astirin, Widya Mega Rahmawati, Puguh Karyanto, Nugroho Andi Purnomo, Hadi Wiwit Hendro Cahyono, Edy Suparmanto, Kristiana Hariyanti   +6 more
openaire   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source