Results 61 to 70 of about 1,142 (215)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
THE THEORY OF SPACE CONCEPTS RELATED TO FORMULA GREEN OPEN SPACE
Journal of architecture&ENVIRONMENT, 2014 The concept of green open space is still stuck on the concept of space-based theory of absolute space by Issac Newton, who see space as a separation between the mass of the building as a container (solid) and open space (void). Meanwhile, the demands of the world's cities today to combine city life with the natural environment in the city increasingly ...
openaire +2 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The impact of noise on green open space value
Journal of Environmental ManagementI investigate the effect of noise on the amenity value of urban green open spaces in Prague, Czech Republic. First, I use standard hedonic pricing model exploiting cross-sectional and quasi-experimental variation in the apartment price data and then I analyse green open spaces quality inferred from a quantitative spatial model.
openaire +2 more sources
Healing Garden as a Green Open Space in Hospital
International Islamic Medical JournalIntroduction: Natural environments within healthcare settings have received growing interest for their potential role in supporting health and well-being. Healing gardens are typically green open spaces within hospitals that promote the physical, mental, and emotional rehabilitation of patients, also benefiting the staff and visitors.
Marselli Widya Lestari +1 more
openaire +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Abstract This research aims to develop principles, develop innovations, and develop these in the arrangement of green open spaces. The type of research used is qualitative and descriptive quantitative research. In this study, the condition of the road median and the level of tree/plant damage were measured directly, while the community's aspirations ...
Giska Putri Lestari +2 more
openaire +2 more sources
Surakarta’s Green Open Spaces: An Exploration of Their Biodiversity
IOP Conference Series: Earth and Environmental ScienceAbstract Surakarta, also known as Solo, is strategically located to serve as a center of national activities. It is a key region of Central Java Province and forms part of the Joglosemar (Yogyakarta-Solo-Semarang) economic triangle. These factors have led to changes in land use for infrastructure development. As a
Okid Parama Astirin +6 more
openaire +1 more source