Results 81 to 90 of about 20,936,693 (304)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A Study on the Structures of Green, Open Space in Urbanization of Green Zone
Journal of the Japanese Institute of Landscape Architects, 1983 市街地における緑地環境は地域的にさまざまな様相を呈している。この実態を市街化過程との関連でとらえるべく, 東京効外にかつて指定された緑地地域のその後の変遷について, 主としてその解除に際していかなる配慮がなされたか, また解除後の市街地の形成過程においていかなる緑地環境か形成されてきたか, 二, 三の事例を検討しながら緑地環境形成にかかわる課題について整理することを試みたものである。
openaire +2 more sources
Permata Jingga Green Open Space as Major Component of Smart Green City in Malang
Jurnal Pembangunan dan Alam Lestari, 2020 Green open space area smart green city is developed to function as Food function, health function, philosophy function, shade function, aesthetic function and protective function which is the main function and support function to optimize the function ...
Sumardi Sumardi +2 more
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 1998 This report contains the results of the second annual Green Acres survey of local government open space funding programs. In this report, the term open space refers to both parkland and farmland. Parkland encompasses developed parks, conservation lands,
core +1 more source
Predicting space climate change [PDF]
, 2011 The recent decline in the open magnetic flux of the Sun heralds the end of the Grand Solar Maximum (GSM) that has persisted throughout the space age, during which the largest‐fluence Solar Energetic Particle (SEP) events have been rare and Galactic ...
L. Barnard +19 more
core +1 more source
THE THEORY OF SPACE CONCEPTS RELATED TO FORMULA GREEN OPEN SPACE
Journal of architecture&ENVIRONMENT, 2014 The concept of green open space is still stuck on the concept of space-based theory of absolute space by Issac Newton, who see space as a separation between the mass of the building as a container (solid) and open space (void). Meanwhile, the demands of the world's cities today to combine city life with the natural environment in the city increasingly ...
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source