Results 161 to 170 of about 199,661 (307)

Updating "processing and consolidation of open data on public procurement in France (2015-2023)" with daily refresh. [PDF]

Data Brief
Deschamps A.
europepmc   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Prompt-Driven ChatGPT Carbon Calculator for Dental Practices: Estimation and Tailored Improvement Strategies. [PDF]

Int Dent J
Duane B, Ashley P, Larkin J.
europepmc   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

Promoting environmental sustainability through school food procurement in low- and middle-income countries: critical reflections. [PDF]

Front Nutr
Swensson LFJ, Tartanac F.
europepmc   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

Building India's Low-Carbon Healthcare System: A Comprehensive Review of National Policies, Operational Frameworks, and Decarbonization Strategies. [PDF]

Ann Glob Health
Thirumoorthi H, Pape Reddy SS.
europepmc   +1 more source

Mitigating Electrochemical Isolation in Ni‐Rich Layered Cathodes for Durable Solid‐State Batteries

Advanced Science, EarlyView.
Electrochemical isolation of Ni‐rich layered cathodes in sulfide solid‐state batteries is uncovered as a previously unrecognized but critical performance‐limiting pathway. This study elucidates its origin and impact and introduces a scalable mitigation strategy using oxygen‐functionalized conductive carbon.
Abhirup Bhadra, Maxime Brunisholz, Aditya Rawal, Jacob Otabil Bonsu, Tongjun Luo, Lars Thomsen, Wesley M. Dose, Dipan Kundu   +7 more
wiley   +1 more source

The carbon footprint of tourism businesses in Pavlodar region (Kazakhstan): Baseline assessment and decarbonization hot spots. [PDF]

PLoS One
Yessimova D, Belyy A, Faurat A, Novikova-Rodi A, Olshanskaya M, Zavyalova L, Grishchenko I, Yessim A.   +7 more
europepmc   +1 more source