Results 171 to 180 of about 5,357,491 (304)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

V-Mail

open access: yes, 1945
Address cover of a censored V-Mail letter from William Green, from "somewhere in France" to his mother in Lincoln, Nebraska ...
William Green
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Green Product Differentiation and Green Product Launch Success. Does Impact on Green Product Innovation Performance ?

open access: yesProceedings of the 2019 International Conference on Organizational Innovation (ICOI 2019), 2019
Tri Maryati, null Nuryakin
openaire   +1 more source

Pengaruh Green Marketing Mix terhadap Green Product Purchase Intention pada Produk Innisfree di Jakarta dengan Consumer’s Attitude sebagai Variabel Mediasi

open access: yes, 2019
This study aimed to know effect of green marketing towards green product purchase intention on Innisfree products with consumer's attitude towards green product as the mediating variable.
Febriani, Stevany
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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