Results 91 to 100 of about 165,329 (308)

Processing and consolidation of open data on public procurement in France (2015–2023)Zenodo

Data in Brief
Public procurement can be defined as the process by which public contracting authorities purchase goods, services, and works from private suppliers.
Adrien Deschamps, Lucas Potin
doaj   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Government Procurement and Corporate Green Innovation: Evidence from Dual Machine Learning

SAGE Open
This study employs a dual machine learning model to examine the influence of government procurement on corporate green innovation and its underlying mechanisms. We utilize data on listed Chinese companies from 2015 to 2022.
Shu Guan, Mingshan Li
doaj   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Sustainable public procurement in public higher education institutions: basic principles and the need for their implementation

Економіка, управління та адміністрування
Today, when the whole humanity must confront the global environmental challenges facing society, it is necessary to introduce new technologies in all areas of activity that will help ensure the preservation of the planet’s ecology.
O.A. Pylypchuk
doaj   +1 more source

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

Advanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie   +14 more
wiley   +1 more source

Green public procurement – legal base and instruments supporting sustainable development in the construction industry in Poland

E3S Web of Conferences, 2016
In the respect of value, public procurement in the construction industry belongs to one of the largest ones in the domestic market. Therefore, green procurement for construction works should become the center of attention of public authorities in a broad
Kozik Renata, Karasińska - Jaśkowiec Izabela   +1 more
doaj   +1 more source

Rapid and Direct Detection of Methamphetamine in Biofluids using a MXene‐Enabled Electrochemical Sensor

Advanced Science, EarlyView.
A MXene‐enhanced electrochemical sensor enables the rapid and direct detection of methamphetamine. Molecular simulations reveal that specific MXene surface functional groups act as key signal amplifiers by facilitating interfacial interactions. The sensor demonstrates high sensitivity and robust performance in complex biological matrices.
Ri Wang, Xiaofei Deng, Bo Chen, Jienan Shen, Wei Xu, Yingjie Zhu, Yi Zhang, Hui Yang   +7 more
wiley   +1 more source

Critical Factors for Green Public Procurement: The Case of Greece

Logistics
Background: Green Public Procurement (GPP) is a sector that has been growing in recent years through policies encouraged by the European Union. In the Greek public sector, the respective National Action Plan (NAP), which sets specific targets for GPP ...
Varvara S. Orfanidou, Dimitrios J. Dimitriou, Nikolaos P. Rachaniotis, Giannis T. Tsoulfas   +3 more
doaj   +1 more source

Green Public Procurement: Case Study of Latvian Municipalities

Economics and Business, 2019
Green public procurement (GPP) is an instrument for public institutions that have made sustainable consumption and financial aids savings, particularly taking into consideration expenses of the total life cycle of the agreement, not just the procurement ...
Pelša Inese
doaj   +1 more source