Results 51 to 60 of about 13,004,235 (249)
Advanced Science, EarlyView.Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao +19 more
wiley +1 more source
Assessment of Green Public Procurement as a Policy Tool: Cost-efficiency and Competition Considerations [PDF]
Public procurement is officially regarded as an effective means to secure environmental improvement. Estimates indicate that public authorities within the European Union typically purchase goods and services corresponding to approximately 16 percent of ...
Lundberg, Sofia +2 more
core
Advanced Science, EarlyView.Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang +12 more
wiley +1 more source
Advanced Science, EarlyView.Tumor‐associated inflammation retains antibody‐targeted or non‐specific antibody conjugated nanoparticles within the tumor microenvironment. Magnetic Particle Imaging (MPI) enables non‐invasive detection and differentiation of tumors from other organs, owing to higher nanoparticle retention by inflammatory cells in the tumor periphery.
Preethi Korangath +9 more
wiley +1 more source
Green Public Procurement and the Innovation Activities of Firms [PDF]
SSRN Electronic Journal, 2019 This paper provides first empirical insights on the relationship between green public procurement (GPP) and firms' innovation activities. Considering that the public sector is a large buyer in the economy, public procurement is able to work as demand-pull factor for new products and thus innovations - given that the procurement is aimed at such ...
openaire +2 more sources
Auction versus Negotiation in Public Procurement: Looking for Empirical Evidence [PDF]
The relative efficiency of auctions and negotiations is still a puzzle in the literature. While auctions are the prescribed procedures and the most used ones for public procurement, in the private sector, where buyers are free to choose their purchasing ...
Anne Yvrande-Billon +2 more
core
Advanced Science, EarlyView.Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang +11 more
wiley +1 more source
Towards Green Public Procurement
Public procurement is employed by Member States as a tool to shape various policies that are not economic in nature. By spending public funds from the budget, Member States have the opportunity to influence the development and shape of the EU’s internal market.
openaire +2 more sources
Benefits of Green Public Procurement
, 2010 Green Public Procurement (GPP) can play a significant a role in efforts to influence the private sector towards more sustainable products and services. Following an account of the environmental impact of Nordic public procurement, the project provides an assessment of the potential of strengthening GPP within three key product groups in Nordic public ...
Bauer, Bjørn +4 more
openaire +3 more sources
Advanced Science, EarlyView.An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan +7 more
wiley +1 more source