Results 51 to 60 of about 239,117 (268)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Culturally responsive and evidence-based English teaching in Bangladesh: A mixed-methods exploration of pedagogical adaptation

Social Sciences and Humanities Open
This study explores how evidence-based English teaching strategies can be culturally adapted to support diverse learners in Bangladeshi secondary classrooms.
Takad Ahmed Chowdhury, Shajadul Alam Sweet, Md Nurul Kabir Emon, Md Nur Alam, S.A. Sadia Biswas   +4 more
doaj   +1 more source

A nationwide dataset on the mental health of the Bangladeshi population due to the COVID-19 pandemic

Data in Brief, 2021
The data presented here concerns the article entitled “Impact of COVID-19 pandemic on mental health among general Bangladeshi population: a cross-sectional study” [1].
Md. Rabiul Islam, Sohel Daria, Rajesh Das, Md. Rakib Hasan   +3 more
doaj   +1 more source

The Green Light on Ketamine: Considerations for On-Road Safety

Current Drug Abuse Reviews, 2015
Ketamine (2-(2-chlorophenyl)-2-(methylamino) (cyclohexanone) is a phenylcyclidine derivative originally developed in the 1960’s as a medication to initiate and maintain optimum anaesthesia in veterinary and paediatric surgery [1]. Ketamine functions as an N-methyl-d-aspartate (NMDA) receptor antagonist, and in low or sub-aesthetic doses, has proven ...
Hayley, Amie, Stough, Con, C. Verster, Joris, van de Loo, Aurora J. A. E., Downey, Luke   +4 more
openaire   +5 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Evaluation of the Pharmacotherapeutic Pattern for Treating Schizophrenia in Bangladesh

Pharmaceutical and Biomedical Research, 2020
Background: Studies of the pharmacotherapeutic pattern on schizophrenic patients are few clinical therapy is one of the bases for the assessment of the treatment of Schizophrenia. Objectives: This study aimed to analyze the demographics of these patients
Salsabil Islam, Md. Sohan, Faysal Ahmed, Zabun Nahar, Md. Rabiul Islam   +4 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Pyrolysis of High-Ash Natural Microalgae from Water Blooms: Effects of Acid Pretreatment

Toxins, 2021
Natural microalgae (NA, cyanobacteria) collected from Taihu Lake (Jiangsu, China) were used for biofuel production through pyrolysis. The microalgae were de-ashed via pretreatment with deionized water and hydrochloric acid, and the samples obtained were ...
Longfei Liu, Yichen Liu, Wenli Wang, Yue Wang, Guiying Li, Changwei Hu   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source