Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
Preparation and Optimization of Mn<sup>2+</sup>-Activated Na<sub>2</sub>ZnGeO<sub>4</sub> Phosphors: Insights into Precursor Selection and Microwave-Assisted Solid-State Synthesis. [PDF]
Nanomaterials (Basel)Wang X +6 more
europepmc +1 more source
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Cryo-EM structures of ρ1 GABA<sub>A</sub> receptors with antagonist and agonist drugs. [PDF]
Nat CommunFan C, Cowgill J, Howard RJ, Lindahl E.
europepmc +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
The influence of supportive leadership on hospitality employees' green innovative work behavior: the mediating role of innovative climate and psychological empowerment. [PDF]
Front PsycholJameel A +5 more
europepmc +1 more source
Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Molecular Oncology, EarlyView.Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza +5 more
wiley +1 more source
Microclimate effects and outdoor thermal comfort of green roof types in hot and dry climates: Modelling in the historic city of Yazd, Iran. [PDF]
PLoS OneKarimian Z, Mahdizadeh S.
europepmc +1 more source