Results 271 to 280 of about 6,963,038 (334)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Greening concept in inventory system for deteriorating items with preservation investment and price and stock dependent demand via marine predators algorithm. [PDF]

Sci Rep
Ali H, Panda GC, Alrasheedi AF, Shaikh AA, Gwak J.   +4 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Cadmium-induced impairment in growth, photosynthetic apparatus and redox regulation in green amaranth (Amaranthus viridis L.) plant attenuated by salicylic acid and methyl jasmonate. [PDF]

PLoS One
Hussain MT, Haque MS, Rabbi MF, Tasnim H, Haque MA, Saha A, Sarwar AG, Uddin MN, Hossain MA.   +8 more
europepmc   +1 more source

Europe’s Green Arteries—A Continental Dataset of Riparian Zones

, 2016
Christof J. Weissteiner, Martin Ickerott, Hannes Ott, Markus Probeck, Gernot Ramminger, Nicola Clerici, Hans Durfourmont, Ana Maria Ribeiro de Sousa   +7 more
openalex   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Green-Light-Activatable Penicillin for Light-Dependent Spatial Control of Bacterial Growth, Biofilm Formation, and <i>In Vivo</i> Infection Treatment. [PDF]

ACS Cent Sci
Schulte AM, Schoenmakers JWA, van Oosten M, Jutte PC, van Dijl JM, Szymanski W, Feringa BL.   +6 more
europepmc   +1 more source

An Incomplete Psychological Novel: a Psychoanalytical Analysis of Hazel Lancaster in John Green�s The Fault in Our Stars

, 2016
Nathania Astria Pangestu, F.X. Dono Sunardi   +1 more
openalex   +2 more sources

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source