Results 121 to 130 of about 16,209 (292)

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong   +6 more
wiley   +1 more source

Evolutionary game analysis and regulatory countermeasure research on ship emission supervision

open access: yesFrontiers in Marine Science
Ship emission supervision is an important component of the development of green shipping. During the implementation of policies in the pollutant emission control areas of ships, in response to the bottlenecks in regulatory manpower, technology, and cost,
Lin Xue, Wei He
doaj   +1 more source

Developing a framework of benchmarking for green shipping

open access: yes, 2015
Given its economies of scale, shipping is the most cost-effective mode to move cargoes across the oceans. It generates tremendous economic benefits to society.
Tai, Wan
core  

Young people's occupational aspirations beyond the aspiration discourse: A sociocultural perspective

open access: yesBritish Educational Research Journal, EarlyView.
Abstract Young people's aspirations have been the focus of many educational, sociological and psychological studies. This paper argues, firstly, that the concept of aspirations holds greater generative potential than suggested by the policy‐oriented ‘aspiration discourse’.
Jelena Popov
wiley   +1 more source

How do secondary schools in England talk about modern languages? A corpus‐assisted discourse analysis of school websites

open access: yesBritish Educational Research Journal, EarlyView.
Abstract Situating the study within an ecological perspective on language education, this article examines how secondary schools in England present Modern Languages (MLs) on official school websites. Focusing on 44 schools in Local Authorities with the lowest percentage average entry for the Languages pillar of the EBacc, we built a text database ...
Zhu Hua, Yunpeng Du, Elin Arfon
wiley   +1 more source

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian   +4 more
wiley   +1 more source

Building a Business Case for Green Shipping Corridors [PDF]

open access: yes
Green shipping corridors—first mover initiatives that seek to advance high-ambition solutions for zero emission shipping on dedicated trade routes—face significant commercial challenges.
Aymer, Deniz   +6 more
core  

Adaptive Genomic Divergence Across Altitudes in Capsella bursa‐pastoris

open access: yesBiological Diversity, EarlyView.
Genomic divergence was observed between high‐altitude and low‐altitude populations of Capsella bursa‐pastoris in China, consistent with an important role of ecological factors. Candidate adaptive loci associated with enhanced energy metabolism, photoprotection, and growth plasticity under altitudinal stress were identified.
Lu Liu   +4 more
wiley   +1 more source

Commentary: Additional observations on the skeleton of a juvenile Gryposaurus notabilis (Ornithischia: Hadrosauridae)

open access: yes
The Anatomical Record, EarlyView.
Jordan C. Mallon   +3 more
wiley   +1 more source

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