Overseas students and net migration : fourth report of session 2012-13 report, together with formal minutes, oral and written evidence [PDF]
, 2012 core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Effectiveness of a flipped classroom combined with case-based learning in the clinical training of pediatric interns: a randomized controlled study. [PDF]
Front Med (Lausanne)Hao Z, Huang Y, Cao S, Zhang Y, Wang D.
europepmc +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Training Radiology Residents in Teaching Skills: Using the Kern Curriculum Model to Develop a Pilot, Residents-as-Teachers Curriculum. [PDF]
CureusPaul CR +5 more
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Enhancing computational thinking through coding education in primary school students: an experimental study on the impact of early programming exposure on problem-solving skills. [PDF]
Front PsycholWang X, Wan F, Dai J.
europepmc +1 more source
Sustainable Erasmus+ Travel - Green Skills Repository
The long-term aspiration of the Sustainable Erasmus+ Travel (SET) project is to improve students' opportunities to engage in more environmentally sustainable habits during their mobility and to change their mindset regarding the trip to the mobility destination as a transformative experience in itself.
Paiva, Ana, Dermati, Salome
openaire +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Child centred policing: supporting trauma informed front line police practices with girls who have lived experiences of child sexual exploitation in the United Kingdom. [PDF]
Front Public HealthGreen T, Kosaraju A, Soutar E.
europepmc +1 more source