Results 71 to 80 of about 655,110 (257)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Journal of Transport and Supply Chain Management, 2018 Background: For South African small and medium enterprises (SMEs) to gain and maintain competitive advantages and succeed, they have to change their practices and adapt their strategies to the dynamic environment of today.
Louis R. Epoh, Chengedzai Mafini
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Humanities & Social Sciences CommunicationsSupply chain green technology innovation is crucial for low-carbon development. However, the mechanisms for achieving collaborative green technological innovation among supply chain members remain underexplored.
Jinyao Huan
doaj +1 more source
Impact of revenue-sharing contracts on green supply chain in manufacturing industry
International Journal of Sustainable Engineering, 2020 This paper discusses the coordination of green level improvement in a manufacturing supply chain, and analyses the impact of a retailer’ s undertaking a manufacturer’s green R&D costs on stability of the green supply chain.
Luqing Rong, Maozeng Xu
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
International Journal of Information Management Data InsightsIn the era of globalisation, the use of technology and concerns for sustainability is eminent in the supply chain management practices. The current study focuses on sustainable and green supply practices in different stages of supply chain management and
Sahil Singh Jasrotia +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Engineering Management in Production and ServicesThis study investigates the impact of lean and green supply chain practices on business process performance and sustainable supply chain performance. The research utilises the resource-based view (RBV) theory to construct a conceptual model wherein lean ...
Aladaileh Mohammad J. +3 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source