Results 41 to 50 of about 961,304 (219)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Ligand-controlled regiodivergent and enantioselective C–H cyanation of secondary amines

Nature Communications
Aliphatic amines, such as N,N-dialkyl secondary amines, represent important scaffolds in bioactive molecules, driving significant interest in their regio- and stereoselective C–H functionalisation.
Yang-Jie Mao, Xiahe Chen, Huan-Le Li, Qi Pan, Kun Zhou, Zhen-Yuan Xu, Yun-Fang Yang, Shao-Jie Lou, Dan-Qian Xu   +8 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Modifying graphene oxide with magnetic nanoparticles and Mg-Al LDHs and its application as an efficient catalyst in organic reactions

Scientific Reports
Graphene oxide was synthesized and modified with Fe3O4 magnetic nanoparticles, followed by integration of Mg-Al-OH LDHs into the GO matrix through solvothermal method.
Mohadeseh Rezaeian, Mahdieh Tajbakhsh, Mohammad Reza Naimi-Jamal   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Thermally stable Ni foam-supported inverse CeAlOx/Ni ensemble as an active structured catalyst for CO2 hydrogenation to methane

Nature Communications
Nickel is the most widely used inexpensive active metal center of the heterogeneous catalysts for CO2 hydrogenation to methane. However, Ni-based catalysts suffer from severe deactivation in CO2 methanation reaction due to the irreversible sintering and ...
Xin Tang, Chuqiao Song, Haibo Li, Wenyu Liu, Xinyu Hu, Qiaoli Chen, Hanfeng Lu, Siyu Yao, Xiao-nian Li, Lili Lin   +9 more
doaj   +1 more source

Electrochemical Activity for Vanadium Redox Flow Batteries

International Journal of Electrochemical Science, 2019
A simple and effective method to roughen graphite felt (GF) by using manganese oxide as an etching agent has been developed for vanadium redox flow battery (VRFB) application.
Lei Chen, Haixia Zhou, Youqun Chu, Shaoping Tong   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Multi-responsive chitosan-based hydrogels for controlled release of vincristine

Communications Chemistry, 2023
Hydrogels exhibit advantageous biocompatibility as carriers of chemotherapeutic agents, and those composed of natural polymers such as chitosan additionally offer biodegradability, environmental benefits, and low cost.
Bahareh Farasati Far, Mohsen Omrani, Mohammad Reza Naimi Jamal, Shahrzad Javanshir   +3 more
doaj   +1 more source