Results 111 to 120 of about 11,080,021 (290)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Ron Green Sr. and Eleanor Green interview
, 2002 Bothell, Washington, United StatesThis interview of Ron and Eleanor Green took place at the Hannan House, Bothell, Washington, in July 2002.
Green, Ron Sr.; Green, Eleanor
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D5.4 – Final OSED – Green Route Charging
Green-GEAR aims at enabling and incentivising optimum green trajectories and airspace use through new ATM procedures; it develops three new SESAR Solutions to this end.
Bolic, T.
core +3 more sources
Urban, Planning and Transport ResearchTelecommunication plays a crucial role in the modern society, and its importance in Ghana’s rapid digital and economic transformation is very relevant.
Joseph Teye Buertey +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Simulating the Effects of a Green Payment Program on the Diffusion Rate of a Conservation Technology [PDF]
The decision to adopt a potentially profitable but unfamiliar conservation technology is cast in a multi-period Bayesian framework. Specifically, dairy farmers who are both risk-averse and susceptible to peer group influence progressively learn about the
Baerenklau, Kenneth A.
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Ohio consumer's guide to buying a solar electric system
, 2004 Title from cover of PDF document (viewed Mar. 17, 2006).; "... Produced by Green Energy Ohio with the support of the Ohio Department of Development Office of Energy Efficiency"--P.
Green Energy Ohio.
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, 2002 A map of Kemang, in South Jakarta, Indonesia, showcasing natural resources and cultural ...
Green Map Indonesia
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source