Results 181 to 190 of about 2,664,104 (296)

A Novel Approach to Interrogating Whole Genome Sequencing Data to Optimise Clinical Utility. [PDF]

Mol Genet Genomic Med
Sonner S, McKenna C, Heggarty S, Hamill C, Flanagan C, McKee S, Kerr K, Alhazzaa R, McKnight AJ, Mone F.   +9 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Genomic evolution and natural history of myeloproliferative neoplasms on therapy. [PDF]

Cancer Discov
Leongamornlert D, Lee J, Kamizela AE, To K, Myers D, Williams N, Nyamondo K, Wang X, Guo J, Dissanayake RK, Price J, Durrani AJ, Lambert J, Spencer Chapman M, Pimanda JE, Baxter EJ, Green AR, Godfrey AL, Nangalia J.   +18 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Population Perspectives on Nurturing Relational Health from Early Life: A Systematic Review Series. [PDF]

Clin Child Fam Psychol Rev
Olsson CA, Macdonald JA, Evans-Whipp T, Fischer A, Letcher P, Spry EA, Zubrick SR, Australian Early Relational Health Network.   +7 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Lessons to be learned: a retrospective study of MBRRACE-UK perinatal mortality surveillance (2015-2024) to identify maternity services most consistently reporting higher- and lower-than-average deaths. [PDF]

J Public Health (Oxf)
McDonagh Hull P, Boulton T, Lashewicz B.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Integrating end-of-life care into intensive care practice: Outcomes following Gold Standards Framework accreditation. [PDF]

J Intensive Care Soc
Reay M, Jennings M, Harpham-Lockyer L, Bowen J.   +3 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source