Results 41 to 50 of about 15,740 (221)
Modeling the ACMG/AMP Variant Classification Guidelines as a Bayesian Classification Framework
We evaluated the American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) variant pathogenicity guidelines for internal consistency and compatibility with Bayesian statistical reasoning.
S. Tavtigian +6 more
semanticscholar +1 more source
AI Alignment Versus AI Ethical Treatment: 10 Challenges
ABSTRACT A morally acceptable course of AI development should avoid two dangers: creating unaligned AI systems that pose a threat to humanity and mistreating AI systems that merit moral consideration in their own right. This paper argues these two dangers interact and that if we create AI systems that merit moral consideration, simultaneously avoiding ...
Adam Bradley, Bradford Saad
wiley +1 more source
Diseño de una estrategia de infusión de midazolam ajustada al modelo farmacocinético de Greenblatt
Introducción: los sistemas de administración automática de fármacos, constituyen herramientas de investigación con un alto impacto en la práctica de la anestesiología. Objetivo: exponer la metodología que permitió el ajuste de los cálculos para el diseño
Jorge Rosa Díaz +1 more
doaj
Abstract Society generally presents sex inaccurately as a binary variable based on one or few trait(s), causing myriad issues, including the pursuit of reductionist biology experiments, the creation of laws that limit the rights of women, people with queer genders, and intersex folks, and greater student endorsement of gender stereotypes in ...
Emily P. Driessen +4 more
wiley +1 more source
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin +11 more
wiley +1 more source
In this paper, multifactor asset pricing models are used to assess and compare the performance - through the analysis of Jensen’s alpha - of three equity portfolios constructed according to the value investing strategies proposed by Joseph Piotroski ...
Carlos Henrique Souza Domingues +3 more
doaj +1 more source
Abstract Introduction Occupational resilience has emerged as a construct that links the capacity to face adversity with the role of meaningful occupations in the adaptation and recovery of individuals, groups, and communities. However, its definition, theoretical frameworks, and applications remain heterogeneous and partial.
Gema Puig‐Esteve, Rodolfo Morrison
wiley +1 more source
The essay examines the relationship between Shakespeare and Fletcher’s lost play The History of Cardenio and Theobald’s 1727 adaptation Double Falsehood, and various twentieth-first century attempts (by Greenblatt and Mee, Doran and Álamo, and Gary ...
Gary Taylor
doaj +1 more source
Simplified Transition and Turbulence Modeling for Oscillatory Pipe Flows
One-dimensional unsteady Reynolds-averaged Navier–Stokes computations were performed for oscillatory transitional and turbulent pipe flows and the results were validated against existing experimental data for a wide variety of oscillatory Reynolds and ...
Alexander Shapiro +2 more
doaj +1 more source
Dedication – Susan L Greenblatt [PDF]
Figure 1. Susan in May, 1994 This volume is dedicated to the memory of Susan L Greenblatt, the wife of Steven L Guberman. Susan attended 6 of the 8 dissociative recombination (DR) meetings. Her advice and wise counsel played a vital role in the organization of several of these meetings. The fifth meeting in Chicago in 2001 was her idea and it would not
openaire +1 more source

