Results 111 to 120 of about 17,645 (300)

Temporal variation in travel greenery across 86 cities in Europe

The positive impacts of urban greenery on human health and wellbeing are well documented in scholarly literature. The focus has mostly been on residential greenery or availability and access to recreational green spaces.
Willberg, Elias, Klein, Robert, Korpilo, Silviya, Toivonen, Tuuli   +3 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Assessment of ecosystem functions of urban greenery

, 2021
The methodology brings about new and practical approaches in assessment of five ecosystem functions and services of town greenery. It covers four regulation functions (microclimate regulation, carbon sequestration, pollution and noise reduction) and one ...
Zemek, František
core  

The Study of Behavioral Approach to the Greenery (Landscape) Image

application/pdfThe aim of this study is to obtain the knowledge regarding the maintenance and organization of greenery (Landscape) in neighborhood areas, by clarifying the relationship between various elements of greenery and the human behavior.
ABE, Daishu, NAKASE, Isao, SHIMOMURA, Yasuhiko, MASUDA, Noboru   +3 more
core   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effects of Window Green View Index on Stress Recovery of College Students from Psychological and Physiological Aspects

Buildings
Students often experience high levels of daily academic pressure, spending extended periods within indoor classroom environments. Windows, as a medium of proximity to nature, play an important role in relieving stress.
Xiaotong Jing, Chao Liu, Jiaxin Li, Weijun Gao, Hiroatsu Fukuda   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Transitioning to building integration of photovoltaics and greenery (BIPVGREEN): case studies up-scaling from cities informal settlements

Environmental Research: Infrastructure and Sustainability
To achieve the objectives of COP28 for transitioning away from fossil fuels and phasing these out, both natural and technological solutions are essential, necessitating a step-change in how we implement social innovation.
Dimitrios Karamanis, Hai-Ying Liu, Nikolaos Skandalos, Achilleas Makis, Vasileios Kapsalis, Delia D’Agostino, Carmen Maduta, Athanasios Tolis, Simona Trandafir, Danny Parker   +9 more
doaj   +1 more source

From industry to greenery: exploring how users experience the Regent’s Canal

Frontiers in Sustainable Cities
Spending time in public places is positively associated with physical and mental health, nature connectedness and pro-environmental behavior. This is particularly important, with the ongoing climate crisis and biodiversity loss.
Yarden Woolf, Michael Short
doaj   +1 more source