Results 141 to 150 of about 1,198,269 (280)

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

open access: yesAdvanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du   +13 more
wiley   +1 more source

Correlation Between Fecal Microbiota and Corticosteroid Responsiveness in Primary Immune Thrombocytopenia: an Exploratory Study

open access: yesAdvanced Science, EarlyView.
This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu   +38 more
wiley   +1 more source

How does environmental performance affect financial performance? Evidence from Japanese manufacturing firms [PDF]

open access: yes
This paper examines the effects of environmental performance on financial performance using the data of Japanese manufacturing firms from 2004 to 2008. As the environmental performance, our study considers the two different environmental issues of waste ...
Iwata, Hiroki, Okada, Keisuke
core   +1 more source

Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α

open access: yesAdvanced Science, EarlyView.
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao   +13 more
wiley   +1 more source

A decomposition analysis of the emission of CO2 [PDF]

open access: yes
In 1997 many countries, including the Netherlands, signed the Kyoto treaty. According to this protocol, the emission of CO2 in the Netherlands in the years 2008-2012 should be on average 6% below the level of 1990.
Alex R. Hoen, Machiel Mulder
core  

Self‐Adaptive Reflectance Film for Passive Temperature Regulation in Diverse Environments

open access: yesAdvanced Science, EarlyView.
The rising demand for space cooling calls for innovative passive thermal systems. Traditional radiative cooling materials lack efficiency and alignment with cooling needs, limiting their energy‐saving. A smart film (PFSF) that integrates radiative cooling, reflectance tuning, and phase transition, offering adaptable temperature control across climates ...
Shuo Yang   +9 more
wiley   +1 more source

Infrared photometry and spectrophotometry of Titan [PDF]

open access: yes
The wide variation in infrared brightness temperature of Titan is explained in terms of a greenhouse effect. Radiometric observations in the infrared and microwave frequencies indicate an alternate hot atmospheric model. Methane, ammonia, hydrogen atoms,
Morrison, D.
core   +1 more source

An Insect Salivary Sheath Protein Triggers Plant Resistance to Insects and Pathogens as a Conserved HAMP

open access: yesAdvanced Science, EarlyView.
The salivary sheath protein myosin from SBPH is critical for the formation of the salivary sheath and feeding. However, myosin functions as a HAMP and triggered plant BAK1‐mediated PTI responses, which include the activation of calcium signaling pathways, MAPK phosphorylation, ROS bursts, and cell death, thereby triggering JA pathway.
Liangxuan Qi   +12 more
wiley   +1 more source

Architecting a Bias‐Free Photoelectrochemical CO2 Reduction System for Sustainable Formic Acid

open access: yesAdvanced Science, EarlyView.
A low‐cost, bias‐free photoelectrochemical system for CO2 reduction to formic acid (FA) is constructed via a TiO2‐CdS/Se‐ZnSe/S photoanode in alkaline solution and Cu6Sn5 catalyst in acidic electrolyte, in which replacing OER with SOR significantly improve the reaction kinetics.
Yinchao Yao   +7 more
wiley   +1 more source

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