Results 311 to 320 of about 2,276,968 (394)

Global Sensitivity Analyses of the APSIM-Wheat Model at Different Soil Moisture Levels. [PDF]

Plants (Basel)
Zhang Y, Ai P, Ma Y, Fu Q, Ma X.
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

A model assessment of the relationship between urban greening and ozone air quality in China: a study of three metropolitan regions. [PDF]

NPJ Clim Atmos Sci
Xu J, Silver B, Tang R, Wang N, Huang X, Ding A, Arnold SR.   +6 more
europepmc   +1 more source

Comparative bioactivity assessment of bixin pigment and associated phytochemicals extracted from annatto seeds using conventional and green solvents

Sonakshi Puri, Sumit Kumar Mandal, Harshit Jain, Pankaj Kumar Sharma, P. R. Deepa   +4 more
openalex   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Spatiotemporal Impacts of Forest Fires on Mountain Vegetation: A Case Study From Langtang National Park, Nepal Himalaya. [PDF]

Ecol Evol
Pokhrel S, Thakuri S, Subedi CK, Kunwar RM, Sharma KP, Chaudhary RP, Ghimire SK.   +6 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Fight smarter, not harder: NPR1-mediated immune balance in citrus greening disease. [PDF]

Plant Physiol
Singh R, Teixeira M.
europepmc   +1 more source

High resolution data visualization and machine learning prediction of free chlorine residual in a green building water system

Shimin Wei, Richard Kinh Gian, Derek Hogue, Ismail Mondal, Ting Xu, Ty Boyer, K. Hamilton   +6 more
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source